waning_hr

Returns the effective hazard ratio at a given time on treatment,
accounting for waning of treatment effect.

Toolkit to support and perform discrete event simulations with and without
resource constraints in the context of health technology assessments (HTA).
The package focuses on cost-effectiveness modelling and aims to be submission-ready
to relevant HTA bodies in alignment with 'NICE TSD 15'
<https://sheffield.ac.uk/nice-dsu/tsds/patient-level-simulation>.
More details an examples can be found in the package website <https://jsanchezalv.github.io/WARDEN/>.

Javier Sanchez Alvarez

WARDEN

Workflows for Health Technology Assessments in R using Discrete
EveNts

Gabriel Lemyre

Valerie Aponte Ribero

waning_hr function

<dl><dt>base_hr</dt>
<dd>Numeric. Initial treatment HR (&lt; 1 means benefit).</dd>
<dt>time_on_tx</dt>
<dd>Numeric. Time the patient has been on treatment.</dd>
<dt>start</dt>
<dd>Numeric. Time at which waning begins (HR = base_hr before
this).</dd>
<dt>duration</dt>
<dd>Numeric. Duration of the waning period (HR reaches 1 at
start + duration).</dd>
<dt>type</dt>
<dd>Character. Waning function: <code>"linear"</code> (default),
<code>"exponential"</code>, or <code>"instant"</code>.</dd></dl>

Arguments

Compute effective hazard ratio with treatment waning — waning_hr

<dl>

<dt>base_hr</dt>
<dd>Numeric. Initial treatment HR (&lt; 1 means benefit).</dd>


<dt>time_on_tx</dt>
<dd>Numeric. Time the patient has been on treatment.</dd>


<dt>start</dt>
<dd>Numeric. Time at which waning begins (HR = base_hr before
this).</dd>


<dt>duration</dt>
<dd>Numeric. Duration of the waning period (HR reaches 1 at
start + duration).</dd>


<dt>type</dt>
<dd>Character. Waning function: <code>"linear"</code> (default),
<code>"exponential"</code>, or <code>"instant"</code>.</dd>

</dl>

waning_hr: Compute effective hazard ratio with treatment waning

Description

Usage

Value

Arguments