drugdata

Data to illustrate the use of WCE.

datasets

A flexible method for modeling cumulative effects of time-varying exposures, weighted according to their relative proximity in time, and represented by time-dependent covariates. The current implementation estimates the weight function in the Cox proportional hazards model. The function that assigns weights to doses taken in the past is estimated using cubic regression splines.

Marie-Pierre Sylvestre

Weighted Cumulative Exposure Models

drugdata function

A data frame with 77038 observations from 500 individuals. The data frame is formatted in an interval format. Contains 7 variables.<dl>
 <dt><code>Id</code></dt>
<dd>a numeric vector to identify observations that belong to the same individual (Id).</dd> <dt><code>Event</code></dt>
<dd>a numeric vector representing the event of interest. Takes the value of 1 in the interval during which the event occurs and is 0 otherwise.</dd> <dt><code>Start</code></dt>
<dd>a numeric vector indicating the beginning of the interval.</dd> <dt><code>Stop</code></dt>
<dd>a numeric vector indicating the end of the interval.</dd> <dt><code>sex</code></dt>
<dd>a numeric vector indicating males (0) and females (1).</dd> <dt><code>age</code></dt>
<dd>a numeric vector representing age at baseline.</dd> <dt><code>dose</code></dt>
<dd>a numeric vector representing time-dependent doses of a drug.</dd> 
</dl>

Format

Sample dataset for use with WCE package — drugdata

A data frame with 77038 observations from 500 individuals. The data frame is formatted in an interval format. Contains 7 variables.<dl>
 <dt><code>Id</code></dt>
<dd>a numeric vector to identify observations that belong to the same individual (Id).</dd>

 <dt><code>Event</code></dt>
<dd>a numeric vector representing the event of interest. Takes the value of 1 in the interval during which the event occurs and is 0 otherwise.</dd>

 <dt><code>Start</code></dt>
<dd>a numeric vector indicating the beginning of the interval.</dd>

 <dt><code>Stop</code></dt>
<dd>a numeric vector indicating the end of the interval.</dd>

 <dt><code>sex</code></dt>
<dd>a numeric vector indicating males (0) and females (1).</dd>

 <dt><code>age</code></dt>
<dd>a numeric vector representing age at baseline.</dd>

 <dt><code>dose</code></dt>
<dd>a numeric vector representing time-dependent doses of a drug.</dd>

 
</dl>

drugdata: Sample dataset for use with WCE package

Description

Usage

Arguments

Format

Details

References

Examples