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WGCNA (version 0.96)

Weighted Gene Co-Expression Network Analysis

Description

Functions necessary to perform Weighted Gene Co-Expression Network Analysis

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Version

Install

install.packages('WGCNA')

Monthly Downloads

16,020

Version

0.96

License

GPL (>= 2)

Maintainer

Peter Langfelder

Last Published

September 23rd, 2010

Functions in WGCNA (0.96)

addGuideLines

Add vertical ``guide lines'' to a dendrogram plot
corPvalueFisher

Fisher's asymptotic p-value for correlation
cor

Fast calculations of Pearson correlation.
corAndPvalue

Calculation of correlations and associated p-values
consensusMEDissimilarity

Consensus dissimilarity of module eigengenes.
collectGarbage

Iterative garbage collection.
exportNetworkToCytoscape

Export network to Cytoscape
matchLabels

Relabel module labels to best match the given reference labels
clusterCoef

Clustering coefficient calculation
greenWhiteRed

Green-white-red color sequence
moduleColor.getMEprefix

Get the prefix used to label module eigengenes.
exportNetworkToVisANT

Export network data in format readable by VisANT
scaleFreePlot

Visual check of scale-free topology
automaticNetworkScreeningGS

One-step automatic network gene screening with external gene significance
corPvalueStudent

Student asymptotic p-value for correlation
alignExpr

Align expression data with given vector
labeledHeatmap

Produce a labeled heatmap plot
metaZfunction

Meta-analysis Z statistic
addTraitToMEs

Add trait information to multi-set module eigengene structure
addGrid

Add grid lines to an existing plot.
pquantile

Parallel quantile, median, mean
plotModuleSignificance

Barplot of module significance
goodSamples

Filter samples with too many missing entries
Inline display of progress

Inline display of progress
TOMsimilarity

Topological overlap matrix similarity and dissimilarity
consensusProjectiveKMeans

Consensus projective K-means (pre-)clustering of expression data
goodSamplesGenesMS

Iterative filtering of samples and genes with too many missing entries across multiple data sets
cutreeStaticColor

Constant height tree cut using color labels
mergeCloseModules

Merge close modules in gene expression data
rgcolors.func

Red and Green Color Specification
collapseRows

Select one representative row per group
TOMsimilarityFromExpr

Topological overlap matrix
goodGenesMS

Filter genes with too many missing entries across multiple sets
goodSamplesMS

Filter samples with too many missing entries across multiple data sets
checkAdjMat

Check adjacency matrix
intramodularConnectivity

Calculation of intramodular connectivity
bicor

Biweight Midcorrelation
correlationPreservation

Preservation of eigengene correlations
hubGeneSignificance

Hubgene significance
labeledBarplot

Barplot with text or color labels.
addErrorBars

Add error bars to a barplot.
TOMplot

Graphical representation of the Topological Overlap Matrix
nearestNeighborConnectivityMS

Connectivity to a constant number of nearest neighbors across multiple data sets
scaleFreeFitIndex

Calculation of fitting statistics for evaluating scale free topology fit.
goodGenes

Filter genes with too many missing entries
pickSoftThreshold

Analysis of scale free topology for soft-thresholding
keepCommonProbes

Keep probes that are shared among given data sets
mutualInfoAdjacency

Calculate weighted adjacency matrices based on mutual information
colQuantileC

Fast colunm-wise quantile of a matrix.
plotClusterTreeSamples

Annotated clustering dendrogram of microarray samples
signedKME

Signed eigengene-based connectivity
bicorAndPvalue

Calculation of biweight midcorrelations and associated p-values
labels2colors

Convert numerical labels to colors.
automaticNetworkScreening

One-step automatic network gene screening
GOenrichmentAnalysis

Calculation of GO enrichment (experimental)
checkSets

Check structure and retrieve sizes of a group of datasets.
multiSetMEs

Calculate module eigengenes.
nPresent

Number of present data entries.
blockwiseModules

Automatic network construction and module detection
plot.mat

Red and Green Color Image of Data Matrix
pickHardThreshold

Analysis of scale free topology for hard-thresholding.
blockwiseConsensusModules

Find consensus modules across several datasets.
AUV2predicted

Prediction of Weighted Mutual Information Adjacency Matrix by Correlation
plotMEpairs

Pairwise scatterplots of eigengenes
recutConsensusTrees

Repeat blockwise consensus module detection from pre-calculated data
recutBlockwiseTrees

Repeat blockwise module detection from pre-calculated data
moduleNumber

Fixed-height cut of a dendrogram.
relativeCorPredictionSuccess

Compare prediction success
plot.cor

Red and Green Color Image of Correlation Matrix
overlapTable

Calculate overlap of modules
conformityBasedNetworkConcepts

Calculation of conformity-based network concepts.
networkConcepts

Calculations of network concepts
adjacency

Calculate network adjacency
fixDataStructure

Put single-set data into a form useful for multiset calculations.
cutreeStatic

Constant-height tree cut
sigmoidAdjacencyFunction

Sigmoid-type adacency function.
randIndex

Rand index of two partitions
labelPoints

Label scatterplot points
removeGreyME

Removes the grey eigengene from a given collection of eigengenes.
orderMEs

Put close eigenvectors next to each other
displayColors

Show colors used to label modules
nearestNeighborConnectivity

Connectivity to a constant number of nearest neighbors
preservationNetworkConnectivity

Network preservation calculations
normalizeLabels

Transform numerical labels into normal order.
signumAdjacencyFunction

Hard-thresholding adjacency function
propVarExplained

Proportion of variance explained by eigengenes.
modulePreservation

Calculation of module preservation statistics
plotDendroAndColors

Dendrogram plot with color annotation of objects
na

Basic Statistical Functions for Handling Missing Values
plotColorUnderTree

Plot color rows under a dendrogram
projectiveKMeans

Projective K-means (pre-)clustering of expression data
goodSamplesGenes

Iterative filtering of samples and genes with too many missing entries
networkScreeningGS

Network gene screening with an external gene significance measure
plotEigengeneNetworks

Eigengene network plot
stdErr

Standard error of the mean of a given vector.
simulateMultiExpr

Simulate multi-set expression data
numbers2colors

Color representation for a numeric variable
simulateDatExpr

Simulation of expression data
vectorTOM

Topological overlap for a subset of the whole set of genes
redWhiteGreen

Red-white-green color sequence
corPredictionSuccess

Qunatification of success of gene screening
simulateDatExpr5Modules

Simplified simulation of expression data
fundamentalNetworkConcepts

Calculation of fundamental network concepts from an adjacency matrix.
simulateSmallLayer

Simulate small modules
verboseBoxplot

Boxplot annotated by a Kruskal-Wallis p-value
vectorizeMatrix

Turn a matrix into a vector of non-redundant components
standardScreeningBinaryTrait

Standard screening for binatry traits
softConnectivity

Calculates connectivity of a weighted network.
standardColors

Colors this library uses for labeling modules.
verboseBarplot

Barplot with error bars, annotated by Kruskal-Wallis or ANOVA p-value
sizeGrWindow

Opens a graphics window with specified dimensions
setCorrelationPreservation

Summary correlation preservation measure
dynamicMergeCut

Threshold for module merging
spaste

Space-less paste
stat.bwss

Between and Within Group Sum of Squares Calculation
standardScreeningNumericTrait

Standard screening for numeric traits
stat.diag.da

Diagonal Discriminant Analysis
networkScreening

Identification of genes related to a trait
simulateModule

Simulate a gene co-expression module
rankPvalue

Estimate the p-value for ranking consistently high (or low) on multiple lists
plotNetworkHeatmap

Network heatmap plot
unsignedAdjacency

Calculation of unsigned adjacency
verboseScatterplot

Scatterplot annotated by regression line and p-value
subsetTOM

Topological overlap for a subset of a whole set of genes
standardScreeningCensoredTime

Standard Screening with regard to a Censored Time Variable
WGCNA-package

Weighted Gene Co-Expression Network Analysis
GTOMdist

Generalized Topological Overlap Measure
consensusOrderMEs

Put close eigenvectors next to each other in several sets.
greenBlackRed

Green-black-red color sequence
moduleEigengenes

Calculate module eigengenes.
simulateEigengeneNetwork

Simulate eigengene network from a causal model