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WGCNA (version 0.99)

Weighted Gene Co-Expression Network Analysis

Description

Functions necessary to perform Weighted Gene Co-Expression Network Analysis

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Version

Install

install.packages('WGCNA')

Monthly Downloads

16,020

Version

0.99

License

GPL (>= 2)

Maintainer

Peter Langfelder

Last Published

December 22nd, 2010

Functions in WGCNA (0.99)

checkSets

Check structure and retrieve sizes of a group of datasets.
signumAdjacencyFunction

Hard-thresholding adjacency function
addTraitToMEs

Add trait information to multi-set module eigengene structure
numbers2colors

Color representation for a numeric variable
addErrorBars

Add error bars to a barplot.
Inline display of progress

Inline display of progress
goodSamplesGenes

Iterative filtering of samples and genes with too many missing entries
checkAdjMat

Check adjacency matrix
sigmoidAdjacencyFunction

Sigmoid-type adacency function.
automaticNetworkScreening

One-step automatic network gene screening
overlapTable

Calculate overlap of modules
goodGenes

Filter genes with too many missing entries
correlationPreservation

Preservation of eigengene correlations
displayColors

Show colors used to label modules
adjacency

Calculate network adjacency
plotMEpairs

Pairwise scatterplots of eigengenes
bicorAndPvalue

Calculation of biweight midcorrelations and associated p-values
consensusProjectiveKMeans

Consensus projective K-means (pre-)clustering of expression data
plotNetworkHeatmap

Network heatmap plot
mutualInfoAdjacency

Calculate weighted adjacency matrices based on mutual information
TOMsimilarity

Topological overlap matrix similarity and dissimilarity
colQuantileC

Fast colunm-wise quantile of a matrix.
simulateModule

Simulate a gene co-expression module
corAndPvalue

Calculation of correlations and associated p-values
cor

Fast calculations of Pearson correlation.
simulateDatExpr

Simulation of expression data
exportNetworkToCytoscape

Export network to Cytoscape
automaticNetworkScreeningGS

One-step automatic network gene screening with external gene significance
GTOMdist

Generalized Topological Overlap Measure
TOMplot

Graphical representation of the Topological Overlap Matrix
consensusMEDissimilarity

Consensus dissimilarity of module eigengenes.
bicor

Biweight Midcorrelation
networkScreeningGS

Network gene screening with an external gene significance measure
recutConsensusTrees

Repeat blockwise consensus module detection from pre-calculated data
AUV2predicted

Prediction of Weighted Mutual Information Adjacency Matrix by Correlation
corPredictionSuccess

Qunatification of success of gene screening
WGCNA-package

Weighted Gene Co-Expression Network Analysis
modulePreservation

Calculation of module preservation statistics
labeledBarplot

Barplot with text or color labels.
blockwiseConsensusModules

Find consensus modules across several datasets.
corPvalueStudent

Student asymptotic p-value for correlation
collectGarbage

Iterative garbage collection.
nearestNeighborConnectivity

Connectivity to a constant number of nearest neighbors
collapseRows

Select one representative row per group
projectiveKMeans

Projective K-means (pre-)clustering of expression data
pickSoftThreshold

Analysis of scale free topology for soft-thresholding
addGrid

Add grid lines to an existing plot.
plotColorUnderTree

Plot color rows under a dendrogram
dynamicMergeCut

Threshold for module merging
goodSamplesMS

Filter samples with too many missing entries across multiple data sets
goodSamplesGenesMS

Iterative filtering of samples and genes with too many missing entries across multiple data sets
cutreeStaticColor

Constant height tree cut using color labels
TOMsimilarityFromExpr

Topological overlap matrix
nearestNeighborConnectivityMS

Connectivity to a constant number of nearest neighbors across multiple data sets
plot.cor

Red and Green Color Image of Correlation Matrix
scaleFreePlot

Visual check of scale-free topology
networkConcepts

Calculations of network concepts
fundamentalNetworkConcepts

Calculation of fundamental network concepts from an adjacency matrix.
pickHardThreshold

Analysis of scale free topology for hard-thresholding.
setCorrelationPreservation

Summary correlation preservation measure
keepCommonProbes

Keep probes that are shared among given data sets
alignExpr

Align expression data with given vector
greenWhiteRed

Green-white-red color sequence
networkScreening

Identification of genes related to a trait
standardColors

Colors this library uses for labeling modules.
hubGeneSignificance

Hubgene significance
plotEigengeneNetworks

Eigengene network plot
labels2colors

Convert numerical labels to colors.
na

Basic Statistical Functions for Handling Missing Values
rgcolors.func

Red and Green Color Specification
addGuideLines

Add vertical ``guide lines'' to a dendrogram plot
mergeCloseModules

Merge close modules in gene expression data
goodGenesMS

Filter genes with too many missing entries across multiple sets
goodSamples

Filter samples with too many missing entries
labelPoints

Label scatterplot points
orderMEs

Put close eigenvectors next to each other
propVarExplained

Proportion of variance explained by eigengenes.
labeledHeatmap

Produce a labeled heatmap plot
moduleEigengenes

Calculate module eigengenes.
metaZfunction

Meta-analysis Z statistic
corPvalueFisher

Fisher's asymptotic p-value for correlation
multiSetMEs

Calculate module eigengenes.
moduleNumber

Fixed-height cut of a dendrogram.
blockwiseModules

Automatic network construction and module detection
moduleColor.getMEprefix

Get the prefix used to label module eigengenes.
simulateDatExpr5Modules

Simplified simulation of expression data
vectorizeMatrix

Turn a matrix into a vector of non-redundant components
normalizeLabels

Transform numerical labels into normal order.
pquantile

Parallel quantile, median, mean
rankPvalue

Estimate the p-value for ranking consistently high (or low) on multiple lists
removeGreyME

Removes the grey eigengene from a given collection of eigengenes.
verboseBarplot

Barplot with error bars, annotated by Kruskal-Wallis or ANOVA p-value
sizeGrWindow

Opens a graphics window with specified dimensions
fixDataStructure

Put single-set data into a form useful for multiset calculations.
matchLabels

Relabel module labels to best match the given reference labels
consensusOrderMEs

Put close eigenvectors next to each other in several sets.
scaleFreeFitIndex

Calculation of fitting statistics for evaluating scale free topology fit.
cutreeStatic

Constant-height tree cut
signedKME

Signed eigengene-based connectivity
nPresent

Number of present data entries.
simulateSmallLayer

Simulate small modules
conformityBasedNetworkConcepts

Calculation of conformity-based network concepts.
simulateEigengeneNetwork

Simulate eigengene network from a causal model
stat.diag.da

Diagonal Discriminant Analysis
stat.bwss

Between and Within Group Sum of Squares Calculation
redWhiteGreen

Red-white-green color sequence
simulateMultiExpr

Simulate multi-set expression data
relativeCorPredictionSuccess

Compare prediction success
plotModuleSignificance

Barplot of module significance
plot.mat

Red and Green Color Image of Data Matrix
vectorTOM

Topological overlap for a subset of the whole set of genes
subsetTOM

Topological overlap for a subset of a whole set of genes
softConnectivity

Calculates connectivity of a weighted network.
verboseBoxplot

Boxplot annotated by a Kruskal-Wallis p-value
spaste

Space-less paste
verboseScatterplot

Scatterplot annotated by regression line and p-value
unsignedAdjacency

Calculation of unsigned adjacency
standardScreeningNumericTrait

Standard screening for numeric traits
stdErr

Standard error of the mean of a given vector.
standardScreeningBinaryTrait

Standard screening for binatry traits
GOenrichmentAnalysis

Calculation of GO enrichment (experimental)
clusterCoef

Clustering coefficient calculation
exportNetworkToVisANT

Export network data in format readable by VisANT
greenBlackRed

Green-black-red color sequence
plotClusterTreeSamples

Annotated clustering dendrogram of microarray samples
plotDendroAndColors

Dendrogram plot with color annotation of objects
recutBlockwiseTrees

Repeat blockwise module detection from pre-calculated data
preservationNetworkConnectivity

Network preservation calculations
intramodularConnectivity

Calculation of intramodular connectivity
randIndex

Rand index of two partitions
standardScreeningCensoredTime

Standard Screening with regard to a Censored Time Variable