YuGene-package: Transforms expression datasets to cumulative proportion for comparison
using YuGene transform
Description
YuGene is a simple transform that answers the question: where is my gene of interest? across a range of datasets without the need to re-normalise datasets under consideration.Details
ll{
Package: YuGene
Type: Package
Version: 1.0
Date: 2012-11-27
License: GPL >= 2
}
This package provides a single function (YuGene). It takes a log transformed dataset (ie multiple microarray samples in an experiment) and converts the values to a cumulative proportion. Values close to zero have the lowest expression, and values close to 1 have the highest expression. When many datasets have been YuGene transformed, relative expression levels (YuGene values) can be directly compared across experiments without re-normalization without significant loss of sensitivity when compared to quantile normalized data.References
McHugh L., Le Cao K. A., and Wells C. A. YuGene: A simple method for comparing gene expression across platforms using a cumulative proportion approach. Submitted Nov 2012.