filter_slopes

This function filters main dataset based on provided slope selections an exclusions.

An interactive 'shiny' application for performing non-compartmental analysis (NCA) on
pre-clinical and clinical pharmacokinetic data. The package builds on 'PKNCA' for core estimators and provides interactive visualizations, CDISC
outputs ('ADNCA', 'PP', 'ADPP') and configurable TLGs (tables, listings, and graphs). Typical use cases include exploratory
analysis, validation, reporting or teaching/demonstration of NCA methods. Methods and core
estimators are described in Denney, Duvvuri, and Buckeridge (2015) "Simple, Automatic
Noncompartmental Analysis: The PKNCA R Package" <doi:10.1007/s10928-015-9432-2>.

Valentin Legras

aNCA

(Pre-)Clinical NCA in a Dynamic Shiny App

Ercan Suekuer

Gerardo Jose Rodriguez

Pascal Baertschi

Jana Spinner

Mateusz Kolomanski

Lucy Aspridis

F. Hoffmann-La Roche AG 

filter_slopes function

<dl><dt>data</dt>
<dd>Data to filter. Must be <code>PKNCAdata</code> list, containing the <code>conc</code> element with
<code>PKNCAconc</code> list and appropriate data frame included under data.</dd>
<dt>slopes</dt>
<dd>A data frame containing slope rules, including <code>TYPE</code>, <code>RANGE</code>,
and <code>REASON</code> columns. May also have grouping columns (expected to match slope_groups)</dd>
<dt>profiles</dt>
<dd>List with available profiles for each <code>SUBJECT</code>.</dd>
<dt>slope_groups</dt>
<dd>List with column names that define the groups.</dd>
<dt>check_reasons</dt>
<dd>Whether to check if all selections have REASONS stated. If this is <code>TRUE</code>
and not all selections have a reason provided, an error will be thrown.</dd></dl>

Arguments

Filter dataset based on slope selections and exclusions — filter_slopes

<dl>

<dt>data</dt>
<dd>Data to filter. Must be <code>PKNCAdata</code> list, containing the <code>conc</code> element with
<code>PKNCAconc</code> list and appropriate data frame included under data.</dd>


<dt>slopes</dt>
<dd>A data frame containing slope rules, including <code>TYPE</code>, <code>RANGE</code>,
and <code>REASON</code> columns. May also have grouping columns (expected to match slope_groups)</dd>


<dt>profiles</dt>
<dd>List with available profiles for each <code>SUBJECT</code>.</dd>


<dt>slope_groups</dt>
<dd>List with column names that define the groups.</dd>


<dt>check_reasons</dt>
<dd>Whether to check if all selections have REASONS stated. If this is <code>TRUE</code>
and not all selections have a reason provided, an error will be thrown.</dd>

</dl>

filter_slopes: Filter dataset based on slope selections and exclusions

Description

Usage

Value

Arguments