aNCA (version 0.1.0)

format_pkncadata_intervals: Create Dose Intervals Dataset

Description

This function creates a dataset with dose intervals and specified pharmacokinetic parameters.

Usage

format_pkncadata_intervals(
  pknca_conc,
  pknca_dose,
  params = c("aucinf.obs", "aucint.last", "auclast", "cmax", "half.life", "tmax",
    "lambda.z", "lambda.z.n.points", "r.squared", "adj.r.squared", "lambda.z.time.first",
    "aucpext.obs", "aucpext.pred", "clast.obs", "cl.obs"),
  start_from_last_dose = TRUE
)

Value

A data frame containing the dose intervals and specified pharmacokinetic parameters.

Arguments

pknca_conc

A PKNCAdose object containing the concentration data.

pknca_dose

A PKNCAdose object containing the dose data.

params

A character vector specifying the pharmacokinetic parameters to include.

start_from_last_dose

Logical defining if start is at time of last dose or C1.

Details

The function performs the following steps:

• Creates a vector with all pharmacokinetic parameters.

• Based on dose times, creates a data frame with start and end times.

• If TRTRINT column is present in data, sets last dose end time to start + TRTRINT, or if TRTRINT is NA then either Inf if only one dose present, or max end time if not.

• If no TRTRINT column in data, sets last dose end time to the time of last sample or Inf if single dose data.

• Adds logical columns for each specified parameter.

Assumes that multiple dose data will have a TRTRINT column or contain multiple doses in dataset

Examples

adnca <- read.csv(system.file("shiny/data/Dummy_data.csv", package = "aNCA"))
pknca_data <- PKNCA_create_data_object(adnca)
pknca_conc <- pknca_data$conc
pknca_dose <- pknca_data$dose
params <- c("aucinf.obs", "cmax", "half.life", "tmax", "lambda.z")
dose_intervals <- format_pkncadata_intervals(pknca_conc, pknca_dose, params)