metadata_nca_parameters

A dataset containing the mapping between PKNCA terms and CDISC terms. It mainly involves:<ul>
<li>Parameters: PPTEST, PPTESTCD</li>
</ul>

datasets

An interactive 'shiny' application for performing non-compartmental analysis (NCA) on
pre-clinical and clinical pharmacokinetic data. The package builds on 'PKNCA' for core estimators and provides interactive visualizations, CDISC
outputs ('ADNCA', 'PP', 'ADPP') and configurable TLGs (tables, listings, and graphs). Typical use cases include exploratory
analysis, validation, reporting or teaching/demonstration of NCA methods. Methods and core
estimators are described in Denney, Duvvuri, and Buckeridge (2015) "Simple, Automatic
Noncompartmental Analysis: The PKNCA R Package" <doi:10.1007/s10928-015-9432-2>.

Valentin Legras

aNCA

(Pre-)Clinical NCA in a Dynamic Shiny App

Ercan Suekuer

Gerardo Jose Rodriguez

Pascal Baertschi

Jana Spinner

Mateusz Kolomanski

Lucy Aspridis

F. Hoffmann-La Roche AG 

metadata_nca_parameters function

A data frame with 123 rows and 6 variables:<dl>
<dt>PKNCA</dt>
<dd>PKNCA term</dd><dt>PPTESTCD</dt>
<dd>CDISC term</dd><dt>PPTEST</dt>
<dd>Official CDISC term</dd><dt>input_names</dt>
<dd>Combination of PPTESTCD + ": " + PPTEST. Used for App inputs</dd><dt>FUN</dt>
<dd>PKNCA function used to calculate the parameter</dd><dt>description</dt>
<dd>PKNCA description of the term</dd><dt>is_cdisc_sure</dt>
<dd>Logical indicating if the term is a CDISC official name</dd><dt>unit_type</dt>
<dd>Type of unit associated with the term</dd><dt>TYPE</dt>
<dd>Type of data associated with the parameter/term</dd><dt>CAT</dt>
<dd>Arbitrary assigned subclass for the parameter/term</dd><dt>Depends</dt>
<dd>PKNCA derived. Designates all directly used parameters in calculation</dd><dt>can_excretion</dt>
<dd>Logical. Indicates if the parameter can be used in excretion analysis</dd><dt>can_non_excretion</dt>
<dd>Logical.
Indicates if the parameter can be used in non-excretion analysis</dd><dt>can_single_dose</dt>
<dd>Logical.
Indicates if the parameter can be used in single dose analysis</dd><dt>can_multiple_dose</dt>
<dd>Logical.
Indicates if the parameter can be used in multiple dose analysis</dd><dt>can_extravascular</dt>
<dd>Logical.
Indicates if the parameter can be used in extravascular analysis</dd>
</dl>

Format

metadata_nca_parameters — metadata_nca_parameters

A data frame with 123 rows and 6 variables:<dl>
<dt>PKNCA</dt>
<dd>PKNCA term</dd>

<dt>PPTESTCD</dt>
<dd>CDISC term</dd>

<dt>PPTEST</dt>
<dd>Official CDISC term</dd>

<dt>input_names</dt>
<dd>Combination of PPTESTCD + ": " + PPTEST. Used for App inputs</dd>

<dt>FUN</dt>
<dd>PKNCA function used to calculate the parameter</dd>

<dt>description</dt>
<dd>PKNCA description of the term</dd>

<dt>is_cdisc_sure</dt>
<dd>Logical indicating if the term is a CDISC official name</dd>

<dt>unit_type</dt>
<dd>Type of unit associated with the term</dd>

<dt>TYPE</dt>
<dd>Type of data associated with the parameter/term</dd>

<dt>CAT</dt>
<dd>Arbitrary assigned subclass for the parameter/term</dd>

<dt>Depends</dt>
<dd>PKNCA derived. Designates all directly used parameters in calculation</dd>

<dt>can_excretion</dt>
<dd>Logical. Indicates if the parameter can be used in excretion analysis</dd>

<dt>can_non_excretion</dt>
<dd>Logical.
Indicates if the parameter can be used in non-excretion analysis</dd>

<dt>can_single_dose</dt>
<dd>Logical.
Indicates if the parameter can be used in single dose analysis</dd>

<dt>can_multiple_dose</dt>
<dd>Logical.
Indicates if the parameter can be used in multiple dose analysis</dd>

<dt>can_extravascular</dt>
<dd>Logical.
Indicates if the parameter can be used in extravascular analysis</dd>


</dl>

metadata_nca_parameters: metadata_nca_parameters

Description

Usage

Arguments

Format