pivot_wider_pknca_results

This function reshapes the structure of the results produced by the main function
of the PKNCA package (pk.nca) in a way that each row represents all the main results
summarized for each profile in each individual/subject. Excluding the ID variables,
each column name corresponds with a calculated parameter and between brackets its
corresponding units. AUC intervals, if present, are be added as additional columns.

An interactive 'shiny' application for performing non-compartmental analysis (NCA) on
pre-clinical and clinical pharmacokinetic data. The package builds on 'PKNCA' for core estimators and provides interactive visualizations, CDISC
outputs ('ADNCA', 'PP', 'ADPP') and configurable TLGs (tables, listings, and graphs). Typical use cases include exploratory
analysis, validation, reporting or teaching/demonstration of NCA methods. Methods and core
estimators are described in Denney, Duvvuri, and Buckeridge (2015) "Simple, Automatic
Noncompartmental Analysis: The PKNCA R Package" <doi:10.1007/s10928-015-9432-2>.

Valentin Legras

aNCA

(Pre-)Clinical NCA in a Dynamic Shiny App

Ercan Suekuer

Gerardo Jose Rodriguez

Pascal Baertschi

Jana Spinner

Mateusz Kolomanski

Lucy Aspridis

F. Hoffmann-La Roche AG 

pivot_wider_pknca_results function

<dl><dt>myres</dt>
<dd>The output of PKNCA::pk.nca. It makes some additional assumptions:<ol>
<li>CDISC denomination of actual and nominal time variables (AFRLT, ARRLT, NFRLT, NRRLT).</li>
<li>Intervals must include a column (<code>type_interval</code>) to differentiate between the
custom AUC ranges ("manual") and main parameter calculations ("main").</li>
<li>Includes <code>PPSTRES</code> and <code>PPSTRESU</code> variables in results dataset.</li>
<li>Columns <code>start_dose</code> and <code>end_dose</code> must express the actual start and end times
of the dose, relative to the last reference dose.</li>
<li>Temporarily: CDISC denomination of PK parameters related to half-life: "LAMZNPT",
"LAMZLL", "LAMZ" Used to derive <code>LAMZNPT</code> and <code>LAMZMTD</code>.</li>
</ol></dd></dl>

Arguments

Reshape PKNCA Results — pivot_wider_pknca_results

<dl>

<dt>myres</dt>
<dd>The output of PKNCA::pk.nca. It makes some additional assumptions:<ol>
<li>CDISC denomination of actual and nominal time variables (AFRLT, ARRLT, NFRLT, NRRLT).</li>
<li>Intervals must include a column (<code>type_interval</code>) to differentiate between the
custom AUC ranges ("manual") and main parameter calculations ("main").</li>
<li>Includes <code>PPSTRES</code> and <code>PPSTRESU</code> variables in results dataset.</li>
<li>Columns <code>start_dose</code> and <code>end_dose</code> must express the actual start and end times
of the dose, relative to the last reference dose.</li>
<li>Temporarily: CDISC denomination of PK parameters related to half-life: "LAMZNPT",
"LAMZLL", "LAMZ" Used to derive <code>LAMZNPT</code> and <code>LAMZMTD</code>.</li>
</ol></dd>

</dl>

pivot_wider_pknca_results: Reshape PKNCA Results

Description

Usage

Value

Arguments