verify_parameters

This helper function updates a PKNCA intervals data frame by verifying and overriding
specific pharmacokinetic parameters depending on whether the sample is identified
as excreta (e.g., urine, feces, bile). Parameters related to excretion
(such as <code>ae</code>, <code>fe</code>, and those starting with <code>"clr."</code>) are selectively enabled
only for excreta samples and set to <code>FALSE</code> otherwise.

An interactive 'shiny' application for performing non-compartmental analysis (NCA) on
pre-clinical and clinical pharmacokinetic data. The package builds on 'PKNCA' for core estimators and provides interactive visualizations, CDISC
outputs ('ADNCA', 'PP', 'ADPP') and configurable TLGs (tables, listings, and graphs). Typical use cases include exploratory
analysis, validation, reporting or teaching/demonstration of NCA methods. Methods and core
estimators are described in Denney, Duvvuri, and Buckeridge (2015) "Simple, Automatic
Noncompartmental Analysis: The PKNCA R Package" <doi:10.1007/s10928-015-9432-2>.

Valentin Legras

aNCA

(Pre-)Clinical NCA in a Dynamic Shiny App

Ercan Suekuer

Gerardo Jose Rodriguez

Pascal Baertschi

Jana Spinner

Mateusz Kolomanski

Lucy Aspridis

F. Hoffmann-La Roche AG 

verify_parameters function

<dl><dt>pknca_intervals</dt>
<dd>A data frame containing PKNCA interval information,
including pharmacokinetic parameters and a <code>PCSPEC</code> column that describes the
specimen type.</dd>
<dt>params</dt>
<dd>A character vector of parameter names selected by the user.
Only these parameters will remain <code>TRUE</code> for excreta types.</dd>
<dt>all_pknca_params</dt>
<dd>A character vector of all pharmacokinetic parameters
that may be present in <code>pknca_intervals</code>. These will be checked and updated accordingly.</dd></dl>

Arguments

Conditionally Verify and Override PK Parameters Based on Sample Type — verify_parameters

<dl>

<dt>pknca_intervals</dt>
<dd>A data frame containing PKNCA interval information,
including pharmacokinetic parameters and a <code>PCSPEC</code> column that describes the
specimen type.</dd>


<dt>params</dt>
<dd>A character vector of parameter names selected by the user.
Only these parameters will remain <code>TRUE</code> for excreta types.</dd>


<dt>all_pknca_params</dt>
<dd>A character vector of all pharmacokinetic parameters
that may be present in <code>pknca_intervals</code>. These will be checked and updated accordingly.</dd>

</dl>

verify_parameters: Conditionally Verify and Override PK Parameters Based on Sample Type

Description

Usage

Value

Arguments