abcdeFBA (version 0.2)

FVA_robustness: FVA_robustness, a function to determine the change in robustness of the network caused by a mutation.

Description

FVA_robustness builds upon FLUX_VAR_ANALYSIS to give the user a convenient function to examine the change in network robustness caused by a user supplied mutation. Graphical results for absolute flux span comparisons may be expected in the working directory

Usage

FVA_robustness(fba_object, mutation)

Arguments

fba_object

Is a list containing the data required to perform flux balance analysis. The elements of the list are mat which is the stoichiometric matrix, dir which gives the direction of the equality constraints, obj specifies the objective function for the simu

mutation

A reaction number obtained using the SEARCH_reaction,or in the non-lethal reaction "list" result of an Exhaustive_single_deletion run. This reaction will be deleted during the FVA analysis

Examples

#Mutant network robustness, removing Formate Exchange which has no effect on fluxes 
	data(Ecoli_core)	
	FVA_robustness(Ecoli_core,25)