prob_all_equi

Used internally. This function takes a <code>matrix</code> as calculated by the
<code>get_draws_binom()</code>, <code>get_draws_norm()</code> or a corresponding custom function
(specified using the <code>fun_draws</code> argument in <code>setup_trial()</code>; see
<code>get_draws_generic()</code>), and an equivalence difference, and calculates the
probability of all arms being equivalent (absolute differences between
highest and lowest value in the same set of posterior draws being less than
the difference considered practically equivalent).

internal

Package that simulates adaptive (multi-arm, multi-stage) clinical
trials using adaptive stopping, adaptive arm dropping, and/or adaptive
randomisation. Developed as part of the INCEPT (Intensive Care Platform
Trial) project (<https://incept.dk/>), primarily supported by a grant
from Sygeforsikringen "danmark" (<https://www.sygeforsikring.dk/>).

Anders Granholm

adaptr

Adaptive Trial Simulator

Benjamin Skov Kaas-Hansen

Aksel Karl Georg Jensen

Theis Lange

prob_all_equi function

<dl><dt>m</dt>
<dd>a matrix with one column per trial arm (named as the <code>arms</code>) and one
row for each draw from the posterior distributions.</dd>
<dt>equivalence_diff</dt>
<dd>single numeric value (<code>&gt; 0</code>) or <code>NULL</code> (default,
corresponding to no equivalence assessment). If a numeric value is
specified, estimated absolute differences smaller than this threshold will
be considered equivalent. For designs with a common <code>control</code> arm, the
differences between each non-control arm and the <code>control</code> arm is used, and
for trials without a common <code>control</code> arm, the difference between the
highest and lowest estimated outcome rates are used and the trial is only
stopped for equivalence if all remaining arms are equivalent.</dd></dl>

Arguments

Calculate the probability that all arms are practically equivalent — prob_all_equi

<dl>

<dt>m</dt>
<dd>a matrix with one column per trial arm (named as the <code>arms</code>) and one
row for each draw from the posterior distributions.</dd>


<dt>equivalence_diff</dt>
<dd>single numeric value (<code>&gt; 0</code>) or <code>NULL</code> (default,
corresponding to no equivalence assessment). If a numeric value is
specified, estimated absolute differences smaller than this threshold will
be considered equivalent. For designs with a common <code>control</code> arm, the
differences between each non-control arm and the <code>control</code> arm is used, and
for trials without a common <code>control</code> arm, the difference between the
highest and lowest estimated outcome rates are used and the trial is only
stopped for equivalence if all remaining arms are equivalent.</dd>

</dl>

prob_all_equi: Calculate the probability that all arms are practically equivalent

Description

Usage

Value

Arguments