c2_extrapol

Also extrapolates results for values outside of [c1f, c1e].

Methods to evaluate the performance characteristics of
various point and interval estimators for optimal adaptive two-stage designs as described
in Meis et al. (2024) <doi:10.1002/sim.10020>.
Specifically, this package is written to work with trial designs created by the 'adoptr' package
(Kunzmann et al. (2021) <doi:10.18637/jss.v098.i09>; Pilz et al. (2021) <doi:10.1002/sim.8953>)).
Apart from the a priori evaluation of performance characteristics, this package also allows for the
evaluation of the implemented estimators on real datasets, and it implements methods
to calculate p-values.

Jan Meis

adestr

Estimation in Optimal Adaptive Two-Stage Designs

Martin Maechler

c2_extrapol function

<dl><dt>design</dt>
<dd>an object of class <code>TwoStageDesignWithCache</code>.</dd>
<dt>x1</dt>
<dd>first-stage test statistic</dd></dl>

Arguments

Calculate the second-stage critical value for a design with cached spline parameters — c2_extrapol

<dl>

<dt>design</dt>
<dd>an object of class <code>TwoStageDesignWithCache</code>.</dd>


<dt>x1</dt>
<dd>first-stage test statistic</dd>

</dl>

c2_extrapol: Calculate the second-stage critical value for a design with cached spline parameters

Description

Usage

Arguments