admiralvaccine (version 0.6.0)

derive_var_aval_adis: Derive AVAL variable for ADIS ADaM domain

Description

Derive AVAL variable for Laboratory Immunology Data ADaM domain. A common rule has been decided for its derivation, based on ISLLOQ, ISULOQ and ISORRES when both ISLLOQ and ISULOQ are present. If ISULOQ is not present, the variables used are ISLLOQ and ISORRES. Please, refers to arguments description for additional details.

Usage

derive_var_aval_adis(
  dataset,
  lower_rule,
  middle_rule,
  upper_rule = NULL,
  round = NULL
)

Value

Dataset with AVAL variable derived.

Arguments

dataset

Input dataset.

lower_rule

Derivation rule when ISSTRESN value is below ISLLOQ. When ISSTRESN is missing, the inequality in ISORRES is checked for the derivation.

middle_rule

Derivation rule when ISSTRESN value is greater than ISLLOQ and lower than ISULOQ. If ISULOQ is not present, derivation rule when ISSTRESN is greater than ISLLOQ. When ISSTRESN is missing, the inequality in ISORRES is checked for the derivation.

upper_rule

Derivation rule when ISSTRESN value is greater than ISULOQ. This is an optional argument since ISULOQ may not be present. When ISSTRESN is missing, the inequality in ISORRES. is checked for the derivation. Default value is NULL.

round

Rounding for AVAL variable. An integer argument which specifies the number of decimals displayed. Default value is NULL.

Author

Federico Baratin

See Also

Other der_var: derive_vars_crit(), derive_vars_event_flag(), derive_vars_max_flag(), derive_vars_merged_vaccine(), derive_vars_params(), derive_vars_vaxdt()

Examples

library(tibble)
library(admiral)
library(admiraldev)
library(dplyr)
library(rlang)

input <- tribble(
  ~USUBJID, ~AVISITN, ~PARAMCD, ~PARAM, ~ISORRES, ~ISSTRESN, ~ISLLOQ, ~ISULOQ,
  "ABC-1001", 10, "J0033VN", "J0033VN Antibody", NA, NA, 2, 100,
  "ABC-1001", 10, "I0019NT", "I0019NT Antibody", "3", 3.0, 4, 200,
  "ABC-1001", 10, "M0019LN", "M0019LN Antibody", ">150", NA, 8, 150,
  "ABC-1001", 10, "R0003MA", "R0003MA Antibody", "140.5", 140.5, 4, 120,
  "ABC-1001", 30, "J0033VN", "J0033VN Antibody", "2", 2.0, 2, 100,
  "ABC-1001", 30, "I0019NT", "I0019NT Antibody", NA, NA, 4, 200,
  "ABC-1001", 30, "M0019LN", "M0019LN Antibody", NA, NA, 8, 150,
  "ABC-1001", 30, "R0003MA", "R0003MA Antibody", "98.2", 98.2, 4, 120,
  "ABC-1001", 10, "J0033VNL", "LOG10 (J0033VN Antibody)", NA, NA, 2, 100,
  "ABC-1001", 10, "I0019NTL", "LOG10 (I0019NT Antibody)", "3", 3.0, 4, 200,
  "ABC-1001", 10, "M0019LNL", "LOG10 (M0019LN Antibody)", ">150", NA, 8, 150,
  "ABC-1001", 10, "R0003MAL", "LOG10 (R0003MA Antibody)", "140.5", 140.5, 4, 120,
  "ABC-1001", 30, "J0033VNL", "LOG10 (J0033VN Antibody)", "2", 2.0, 2, 100,
  "ABC-1001", 30, "I0019NTL", "LOG10 (I0019NT Antibody)", NA, NA, 4, 200,
  "ABC-1001", 30, "M0019LNL", "LOG10 (M0019LN Antibody)", NA, NA, 8, 150,
  "ABC-1001", 30, "R0003MAL", "LOG10 (R0003MA Antibody)", "98.2", 98.2, 4, 120,
  "ABC-1002", 10, "J0033VN", "J0033VN Antibody", "3", 3.0, 2, 100,
  "ABC-1002", 10, "I0019NT", "I0019NT Antibody", NA, NA, 4, 200,
  "ABC-1002", 10, "M0019LN", "M0019LN Antibody", NA, NA, 8, 150,
  "ABC-1002", 10, "R0003MA", "R0003MA Antibody", "48.9", 48.9, 4, 120,
  "ABC-1002", 30, "J0033VN", "J0033VN Antibody", NA, NA, 2, 100,
  "ABC-1002", 30, "I0019NT", "I0019NT Antibody", NA, NA, 4, 200,
  "ABC-1002", 30, "M0019LN", "M0019LN Antibody", "5", 5.0, 8, 150,
  "ABC-1002", 30, "R0003MA", "R0003MA Antibody", "228.1", 228.1, 4, 120
)

derive_var_aval_adis(
  dataset = input,
  lower_rule = ISLLOQ / 2,
  middle_rule = ISSTRESN,
  upper_rule = ISULOQ,
  round = 2
)