exp_sample_size_norm_global

<code>sample_size_norm_global</code> calculates the power if the time of the final
analysis is given and otherwise the sample size.
The computed power for <code>effect_size</code> is an approximate lower bound.
Sample size is also calculated on the basis of the bound.

Provides the functions for planning and conducting a
clinical trial with adaptive sample size determination. Maximal statistical
efficiency will be exploited even when dramatic or multiple adaptations
are made. Such a trial consists of adaptive determination of sample size
at an interim analysis and implementation of frequentist statistical test at the
interim and final analysis with a prefixed significance level. The required
assumptions for the stage-wise test statistics are independent and stationary
increments and normality. Predetermination of adaptation rule is not required.

Kosuke Kashiwabara

adpss

Design and Analysis of Locally or Globally Efficient Adaptive
Designs

exp_sample_size_norm_global function

<dl><dt>initial_test</dt>
<dd>Designate the initial working test generated by <code>work_test_norm_global</code> function.</dd>
<dt>effect_size</dt>
<dd>The effect size, on the basis of which the power or sample size calculation will be performed. In globally efficient designs, any real value is allowed.</dd>
<dt>time</dt>
<dd>The time of the current analysis.</dd>
<dt>final_time</dt>
<dd>The time of the final analysis.</dd>
<dt>input_check</dt>
<dd>Indicate whether or not the arguments input by user contain invalid values.</dd></dl>

Arguments

Calculate expected sample size for a globally efficient adaptive design when working design is followed until the final interim analysis time and the final analysis time is fixed. — exp_sample_size_norm_global

<dl>

<dt>initial_test</dt>
<dd>Designate the initial working test generated by <code>work_test_norm_global</code> function.</dd>


<dt>effect_size</dt>
<dd>The effect size, on the basis of which the power or sample size calculation will be performed. In globally efficient designs, any real value is allowed.</dd>


<dt>time</dt>
<dd>The time of the current analysis.</dd>


<dt>final_time</dt>
<dd>The time of the final analysis.</dd>


<dt>input_check</dt>
<dd>Indicate whether or not the arguments input by user contain invalid values.</dd>

</dl>

Calculate expected sample size for a globally efficient adaptive design when working design is followed until the final interim analysis time and the final analysis time is fixed.

exp_sample_size_norm_global: Calculate expected sample size for a globally efficient adaptive design when working design is followed until the final interim analysis time and the final analysis time is fixed.

Description

Usage

Value

Arguments

See Also