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#Purpose The overall goal of the aop package is to provide a single package to facilitate the use of Adverse Outcome Pathways for chemical risk assessment, hazard identification, and risk screening in an environmental health context. Currently, the aop package provides capabilities for:

  1. Identifying key events sufficient to infer an adverse outcome
  2. Concentration-response analysis to identify the point of departure

Note: The point of departure is the point at which the exposed population begins to deviate from the exposed non-response population (in other words, the concentration at which adversity is likely to be seen in the population).

#Examples For examples, please see the package documentation.

#Installation

#from github
library(devtools)
install_github("DataSciBurgoon/aop", build_vignettes=TRUE)

#Overview Please see the vignettes for tutorials on use.

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Version

Install

install.packages('aop')

Monthly Downloads

5

Version

1.0.0

License

CC0

Maintainer

Lyle D Burgoon

Last Published

December 5th, 2016

Functions in aop (1.0.0)

bootstrap_metaregression

Perform Bootstrap Metaregression
convert_cytoscape_to_aop

Convert Cytoscape Graph to an AOP
aop_cytoscape-class

aop_cytoscape class
getAOPNodeName

Get Node Name from ID
plot_metaregression_confidence_envelope

Plot the metaregression confidence envelope and median results from the bootstrap metaregression models.
bmr-class

bmr class
convert_aop_to_graph

Convert AOP to Graph
oxybenzone

High Throughput Screening Data (Tox21) for Assessing the Estrogenicity of Oxybenzone
calculate_confidence_and_median

Calculate the confidence envelope and the median for the bootstrap metaregression concentration response models.
pod_slope_analysis

This is intended as an internal function to facilitate the identification of the concentration where the asymptote is likely to end based on a slope threshold, so that the mean of the upper confidence limit for the asymptote can be calculated.
aop_backdoor

Backdoor Causal Network Analysis for AOPs
pod_envelope_analysis

This function calculates the chemical's point of departure.
internal_model_fits

An internal function for calculating interpolation values.
slope_pod_analysis

Slope-based POD analysis
plot_slope_analysis

Plot the median slope
plot_metaregression_spaghetti_plot

Make a spaghetti plot for the metaregression results