pairedAlleleSpecificCopyNumbers: Calculating tumor-normal paired allele-specific copy number stratified on genotypes
Description
Calculating tumor-normal paired allele-specific copy number stratified on genotypes.
The method is a single-sample (single-pair) method.
It requires paired tumor-normal parent-specific copy number signals.
Usage
"pairedAlleleSpecificCopyNumbers"(thetaT, betaT, thetaN, betaN, muN=callNaiveGenotypes(betaN), ...)
Arguments
thetaT, betaT
Theta and allele-B fraction signals for the tumor.
thetaN, betaN
Total and allele-B fraction signals for the
matched normal.
muN
An optional vector
of length J containing
normal genotypes calls in (0,1/2,1,NA
) for (AA,AB,BB). Value
Returns a data.frame
with elements CT
, betaT
and muN
.
See Also
This definition of calculating tumor-normal paired ASCN is related
to how the normalizeTumorBoost
() method calculates normalized
tumor BAFs.