Estimate starting parameters using PKNCA
# S3 method for pknca
nlmixr2Est(env, ...)A model with updated starting parameters. In the model a new element named "nca" will be available which includes the PKNCA results used for the calculation.
Environment for the nlmixr2 estimation routines.
This needs to have:
- rxode2 ui object in `$ui`
- data to fit in the estimation routine in `$data`
- control for the estimation routine's control options in `$ui`
Other arguments provided to `nlmixr2Est()` provided for flexibility but not currently used inside nlmixr
Parameters are estimated as follows:
ka 4 half-lives to Tmax but not higher than 3: log(2)/(tmax/4)
vc Inverse of dose-normalized Cmax
cl Estimated as the median clearance
vp,vp22- and 4-fold the vc, respectively by default,
controlled by the vpMult and vp2Mult arguments to
pkncaControl
q,q2 0.5- and 0.25-fold the cl, respectively by default,
controlled by the qMult and q2Mult arguments to
pkncaControl
The bounds for the parameter estimates are set to 10% of the first percentile and 10 times the 99th percentile. (For ka, the lower bound is set to the lower of 10% of the first percentile or 0.03 and the upper bound is not modified from 10 times the 99th percentile.)
Parameter estimation methods may be changed in a future version.