pkncaControl: PKNCA estimation control

Description

PKNCA estimation control

Usage

pkncaControl(
  concu = NA_character_,
  doseu = NA_character_,
  timeu = NA_character_,
  volumeu = NA_character_,
  vpMult = 2,
  qMult = 1/2,
  vp2Mult = 4,
  q2Mult = 1/4,
  dvParam = "cp",
  groups = character(),
  sparse = FALSE,
  ncaData = NULL,
  ncaResults = NULL,
  rxControl = rxode2::rxControl()
)

Value

A list of parameters

Arguments

concu, doseu, timeu: concentration, dose, and time units from the source data (passed to PKNCA::pknca_units_table()).
volumeu: compartment volume for the model (if NULL, simplified units from source data will be used)
vpMult, qMult, vp2Mult, q2Mult: Multipliers for vc and cl to provide initial estimates for vp, q, vp2, and q2
dvParam: The parameter name in the model that should be modified for concentration unit conversions. It must be assigned on a line by itself, separate from the residual error model line.
groups: Grouping columns for NCA summaries by group (required if sparse = TRUE)
sparse: Are the concentration-time data sparse PK (commonly used in small nonclinical species or with terminal or difficult sampling) or dense PK (commonly used in clinical studies or larger nonclinical species)?
ncaData: Data to use for calculating NCA parameters. Typical use is when a subset of the original data are informative for NCA.
ncaResults: Already computed NCA results (a PKNCAresults object) to bypass automatic calculations. At least the following parameters must be calculated in the NCA: tmax, cmax.dn, cl.last
rxControl: Control options sent to rxode2::rxControl()