Usage
create.utility.function(model, n.min, sig.level, safety.max, cE, cS, p,
fixed.cost, cost.per.sample)
Arguments
model
A model object created using create.normal.model or create.normal.model.from.file.
n.min
The minimum group sample size for each phase III group trial
required by the regulatory authority in order to consider market approval.
sig.level
The significance level used by the regulatory authority when
performing the one-sided hypothesis tests for acceptable efficacy and
safety levels in the phase III trial.
safety.max
A parameter defining the maximum safety threshold in the
significance test for an acceptable safety level.
cE
A constant defining the utility gain per unit of efficacy.
cS
A constant defining the utility gain per unit of safety. The
absolute value of this number defines the utility loss, and hence
cS should typically be less than or equal to zero.
p
A number between 0 and 1 which weighs the relative contribution of
the observed responses and the true population means to the utility
upon regulatory approval. A value of 1 corresponds to no contribution
made by the population means.
fixed.cost
The fixed cost of performing the phase III trials.
cost.per.sample
The cost per observation in the phase III trials.