createTrial

This function creates an object of class <code>scenario_list</code>
for a single trial outcome, which can subsequently be analyzed with other functions of
<code>bhmbasket</code>, e.g. <code>performAnalyses</code>

Provides functions for the evaluation of basket
trial designs with binary endpoints. Operating characteristics of a
basket trial design are assessed by simulating trial data according to
scenarios, analyzing the data with Bayesian hierarchical models (BHMs), and
assessing decision probabilities on stratum and trial-level based on Go / No-go decision making.
The package is build for high flexibility regarding decision rules,
number of interim analyses, number of strata, and recruitment.
The BHMs proposed by
Berry et al. (2013) <doi:10.1177/1740774513497539>
and Neuenschwander et al. (2016) <doi:10.1002/pst.1730>,
as well as a model that combines both approaches are implemented.
Functions are provided to implement Bayesian decision rules as for example
proposed by Fisch et al. (2015) <doi:10.1177/2168479014533970>.
In addition, posterior point estimates (mean/median) and credible intervals
for response rates and some model parameters can be calculated.
For simulated trial data, bias and mean squared errors of posterior
point estimates for response rates can be provided.

Stephan Wojciekowski

bhmbasket

Bayesian Hierarchical Models for Basket Trials

Tathagata Chattopadhyay

createTrial function

<dl><dt>n_subjects</dt>
<dd>A vector of integers for the number of subjects in the trial outcome</dd>
<dt>n_responders</dt>
<dd>A vector of integers for the number of responders in the trial outcome</dd></dl>

Arguments

Author

createTrial — createTrial

<dl>

<dt>n_subjects</dt>
<dd>A vector of integers for the number of subjects in the trial outcome</dd>


<dt>n_responders</dt>
<dd>A vector of integers for the number of responders in the trial outcome</dd>

</dl>

createTrial: createTrial

Description

Usage

Value

Arguments

Author

Details

See Also

Examples