lor_estimation

Function to estimate the subgroup log-odds ratio for binary data.

Subgroup analyses are routinely performed in clinical trial
analyses. From a methodological perspective, two key issues of
subgroup analyses are multiplicity (even if only predefined subgroups
are investigated) and the low sample sizes of subgroups which lead to
highly variable estimates, see e.g. Yusuf et al (1991)
<doi:10.1001/jama.1991.03470010097038>. This package implements
subgroup estimates based on Bayesian shrinkage priors, see Carvalho et
al (2019) <https://proceedings.mlr.press/v5/carvalho09a.html>. In
addition, estimates based on penalized likelihood inference are
available, based on Simon et al (2011) <doi:10.18637/jss.v039.i05>.
The corresponding shrinkage based forest plots address the
aforementioned issues and can complement standard forest plots in
practical clinical trial analyses.

Isaac Gravestock

bonsaiforest

Shrinkage Based Forest Plots

Mar Vazquez Rabunal

Daniel Sabanés Bové

Marcel Wolbers

F. Hoffmann-La Roche AG 

lor_estimation function

<dl><dt>x_subg</dt>
<dd>(<code>matrix</code>) the matrix with the subgroup covariates.</dd>
<dt>dummy_subg</dt>
<dd>(<code>matrix</code>) the dummy matrix with the subgroup
covariates.</dd>
<dt>est_coef</dt>
<dd>(<code>matrix</code>) the estimated coefficients from the fitted
model.</dd></dl>

Arguments

Estimation of Log-Odds Ratio — lor_estimation

<dl>

<dt>x_subg</dt>
<dd>(<code>matrix</code>) the matrix with the subgroup covariates.</dd>


<dt>dummy_subg</dt>
<dd>(<code>matrix</code>) the dummy matrix with the subgroup
covariates.</dd>


<dt>est_coef</dt>
<dd>(<code>matrix</code>) the estimated coefficients from the fitted
model.</dd>

</dl>

lor_estimation: Estimation of Log-Odds Ratio

Description

Usage

Value

Arguments

Examples