subgroups

Function to obtain the estimated treatment effect in each one of the
considered subgroups.

Subgroup analyses are routinely performed in clinical trial
analyses. From a methodological perspective, two key issues of
subgroup analyses are multiplicity (even if only predefined subgroups
are investigated) and the low sample sizes of subgroups which lead to
highly variable estimates, see e.g. Yusuf et al (1991)
<doi:10.1001/jama.1991.03470010097038>. This package implements
subgroup estimates based on Bayesian shrinkage priors, see Carvalho et
al (2019) <https://proceedings.mlr.press/v5/carvalho09a.html>. In
addition, estimates based on penalized likelihood inference are
available, based on Simon et al (2011) <doi:10.18637/jss.v039.i05>.
The corresponding shrinkage based forest plots address the
aforementioned issues and can complement standard forest plots in
practical clinical trial analyses.

Isaac Gravestock

bonsaiforest

Shrinkage Based Forest Plots

Mar Vazquez Rabunal

Daniel Sabanés Bové

Marcel Wolbers

F. Hoffmann-La Roche AG 

subgroups function

<dl><dt>object</dt>
<dd>(<code>bonsaiforest</code>) the fitted bonsaiforest object.</dd>
<dt>est_coef</dt>
<dd>(<code>matrix</code>) the estimated coefficients from the fitted
model.</dd>
<dt>h0</dt>
<dd>(<code>numeric</code>) the vector with the cumulative baseline hazard.
Present just for <code>resptype</code> survival.</dd>
<dt>gamma</dt>
<dd>(<code>scalar</code>) numeric value defining the weights to obtain
the average hazard ratio. Default is 1 (in this case the average hazard
ratio obtained can be interpreted as the odds of concordance).</dd></dl>

Arguments

Subgroup Treatment Effect — subgroups

<dl>

<dt>object</dt>
<dd>(<code>bonsaiforest</code>) the fitted bonsaiforest object.</dd>


<dt>est_coef</dt>
<dd>(<code>matrix</code>) the estimated coefficients from the fitted
model.</dd>


<dt>h0</dt>
<dd>(<code>numeric</code>) the vector with the cumulative baseline hazard.
Present just for <code>resptype</code> survival.</dd>


<dt>gamma</dt>
<dd>(<code>scalar</code>) numeric value defining the weights to obtain
the average hazard ratio. Default is 1 (in this case the average hazard
ratio obtained can be interpreted as the odds of concordance).</dd>

</dl>

subgroups: Subgroup Treatment Effect

Description

Usage

Value

Arguments

Examples