Optimized GWAS cohort subset selection for resequencing studies
Description
This package contains functionality to select a subsample
of a genotyped cohort e.g. from a GWAS that is preferential for
resequencing under the assumtion that causal variants share a
haplotype with the risk allele of associated variants. The
subsample is selected such that is contains risk alleles at
maximum frequency for all SNPs specified. Phentoypes can also
be included as additional variables to obtain a higher fraction
of extreme phenotypes. An arbitrary number of SNPs and/or
phentoypes can be specified for enrichment in a single
subsample.