fillIOVOccColumns

Problem in RxODE (LOCF mode) / mrgsolve (LOCF mode), if 2 rows have the same time (often: OBS then DOSE), first row covariate value is taken!
Workaround: identify these rows (group by ID and TIME) and apply a fill in the UP direction.

internal

A generic, easy-to-use and intuitive
pharmacokinetic/pharmacodynamic (PK/PD) simulation platform based on R
packages 'rxode2' and 'mrgsolve'. CAMPSIS provides an abstraction
layer over the underlying processes of writing a PK/PD model,
assembling a custom dataset and running a simulation. CAMPSIS has a
strong dependency to the R package 'campsismod', which allows to
read/write a model from/to files and adapt it further on the fly in
the R environment. Package 'campsis' allows the user to assemble a
dataset in an intuitive manner. Once the user’s dataset is ready, the
package is in charge of preparing the simulation, calling 'rxode2' or
'mrgsolve' (at the user's choice) and returning the results, for the
given model, dataset and desired simulation settings.

Nicolas Luyckx

campsis

Generic PK/PD Simulation Platform CAMPSIS

fillIOVOccColumns function

<dl><dt>table</dt>
<dd>current table</dd>
<dt>columnNames</dt>
<dd>the column names to fill</dd>
<dt>downDirectionFirst</dt>
<dd>TRUE: first fill down then fill up (by ID &amp; TIME). FALSE: First fill up (by ID &amp; TIME), then fill down</dd></dl>

Arguments

Fill IOV/Occasion columns. — fillIOVOccColumns

<dl>

<dt>table</dt>
<dd>current table</dd>


<dt>columnNames</dt>
<dd>the column names to fill</dd>


<dt>downDirectionFirst</dt>
<dd>TRUE: first fill down then fill up (by ID &amp; TIME). FALSE: First fill up (by ID &amp; TIME), then fill down</dd>

</dl>

fillIOVOccColumns: Fill IOV/Occasion columns.

Description

Usage

Value

Arguments