check_matrix_is_positive_definite

Check OMEGA/SIGMA matrix for positive definiteness.

internal

A generic, easy-to-use and expandable implementation of a
pharmacokinetic (PK) / pharmacodynamic (PD) model based on the S4
class system. This package allows the user to read and write
pharmacometric models from and to files, including a JSON-based
interface to import Campsis models defined using a formal JSON schema
distributed with the package. Models can be adapted further on the fly
in the R environment using an intuitive API to add, modify or delete
equations, ordinary differential equations (ODEs), model parameters or
compartment properties (such as infusion duration or rate,
bioavailability and initial values). The package also provides export
facilities for use with the simulation packages 'rxode2' and
'mrgsolve'. The package itself is licensed under the GPL (>= 3); the
JSON schema file shipped in inst/extdata is licensed separately under
the Creative Commons Attribution 4.0 International (CC BY 4.0).  This
package is designed and intended to be used with the package
'campsis', a PK/PD simulation platform built on top of 'rxode2' and
'mrgsolve'.

Nicolas Luyckx

campsismod

Generic Implementation of a PK/PD Model

check_matrix_is_positive_definite function

<dl><dt>table</dt>
<dd>data frame with the sampled parameters to check</dd>
<dt>parameters</dt>
<dd>double array parameters to check for positive definiteness</dd></dl>

Arguments

Check OMEGA/SIGMA matrix for positive definiteness. — check_matrix_is_positive_definite

<dl>

<dt>table</dt>
<dd>data frame with the sampled parameters to check</dd>


<dt>parameters</dt>
<dd>double array parameters to check for positive definiteness</dd>

</dl>

check_matrix_is_positive_definite: Check OMEGA/SIGMA matrix for positive definiteness.

Description

Usage

Arguments