read_parameters

full path to the .yml file holding CAPE parameters (is not needed if yaml_parameters is provided)

filename

yaml string holding CAPE parameters (can be NULL)

yaml_parameters

This function returns reads in the YAML file
and checks for any parameters that might not
be included. This may not matter for the given
run, but it's handy to be able to check for 
any and all potential variables.

Combined Analysis of Pleiotropy and Epistasis infers predictive
networks between genetic variants and phenotypes. It can be used with
standard two-parent populations as well as multi-parent populations, such
as the Diversity Outbred (DO) mice, Collaborative Cross (CC) mice, or the
multi-parent advanced generation intercross (MAGIC) population of Arabidopsis
thaliana. It uses complementary information of pleiotropic gene variants across
different phenotypes to resolve models of epistatic interactions between alleles.
To do this, cape reparametrizes main effect and interaction coefficients from
pairwise variant regressions into directed influence parameters. These
parameters describe how alleles influence each other, in terms of suppression
and enhancement, as well as how gene variants influence phenotypes. All of the
final interactions are reported as directed interactions between pairs of
parental alleles. For detailed descriptions of the methods used in this package
please see the following references.
Carter, G. W., Hays, M., Sherman, A. & Galitski, T. (2012) <doi:10.1371/journal.pgen.1003010>.
Tyler, A. L., Lu, W., Hendrick, J. J., Philip, V. M. & Carter, G. W. (2013) <doi:10.1371/journal.pcbi.1003270>.

Anna L Tyler

cape

Combined Analysis of Pleiotropy and Epistasis for Diversity
Outbred Mice

Anna Tyler

Jake Emerson

Baha El Kassaby

Ann Wells

Georgi Kolishovski

Vivek Philip

Gregory Carter

read_parameters function

<dl><dt>filename</dt>
<dd>full path to the .yml file holding CAPE parameters (is not needed if yaml_parameters is provided)</dd>
<dt>yaml_parameters</dt>
<dd>yaml string holding CAPE parameters (can be NULL)</dd></dl>

Arguments

Read the parameter file, add missing entries — read_parameters

<dl>

<dt>filename</dt>
<dd>full path to the .yml file holding CAPE parameters (is not needed if yaml_parameters is provided)</dd>


<dt>yaml_parameters</dt>
<dd>yaml string holding CAPE parameters (can be NULL)</dd>

</dl>

read_parameters: Read the parameter file, add missing entries

Description

Usage

Value

Arguments

Examples