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chemmodlab (version 2.0.0)

A Cheminformatics Modeling Laboratory for Fitting and Assessing Machine Learning Models

Description

Contains a set of methods for fitting models and methods for validating the resulting models. The statistical methodologies comprise a comprehensive collection of approaches whose validity and utility have been accepted by experts in the Cheminformatics field. As promising new methodologies emerge from the statistical and data-mining communities, they will be incorporated into the laboratory. These methods are aimed at discovering quantitative structure-activity relationships (QSARs). However, the user can directly input their own choices of descriptors and responses, so the capability for comparing models is effectively unlimited.

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Install

install.packages('chemmodlab')

Monthly Downloads

87

Version

2.0.0

License

GPL-3

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Maintainer

Jeremy Ash

Last Published

May 1st, 2022

Functions in chemmodlab (2.0.0)

ApplicabilityDomain

Compute applicability domain for a chemmodlab model
HitEnrich

Plot hit enrichment curves from observed scores and activities
MakeModelDefaults

Model parameters for ModelTrain
aid364

Cytotoxicity assay using the Jurkat human T-Cell line
HitEnrichDiff

Plot differences between hit enrichment curves
plot.chemmodlab

Plot method for the chemmodlab class.
pparg

Docking scores for 3212 ligands for target PPARg
ModelTrain

Fit predictive models to sets of descriptors.
chemmodlab

Constructor for the chemmodlab object
PerfCurveTest

Perform a hypothesis test for the difference between two performance curves.
PerfCurveBands

Construct a confidence band for a recall or precision curve
CombineSplits

ANOVA and multiple comparisons for chemmodlab objects