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cir (version 2.1.1)

Centered Isotonic Regression and Dose-Response Utilities

Description

Isotonic regression (IR) and its improvement: centered isotonic regression (CIR). CIR is recommended in particular with small samples. Also, interval estimates for both, and additional utilities such as plotting dose-response data.

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Version

Install

install.packages('cir')

Monthly Downloads

315

Version

2.1.1

License

GPL-2

Maintainer

Assaf P. Oron

Last Published

January 6th, 2021

Functions in cir (2.1.1)

cirPAVA

Returns centered-isotonic-regression estimate

deltaInverse

Calculate inverse (dose-finding) intervals, using local inversion and the Delta method

DRshrink

Shrinkage fix to bias in observed rates under adaptive dose-finding design

morrisCI

Analytical confidence intervals using the Morris (1988) algorithm

isotInterval

Returns analytical interval estimates, given isotonic-regression (centered or not) point estimates

iterCIR

Centered-isotonic-regression (CIR): iterative version for better bias correction

is.DRtrace

Constructor functions and class-checking functions for DRtrace and doseResponse classes

cir-package

Isotonic Regression, Centered Isotonic Regression, and Dose-Response Utilities

doseFind

Inverse (dose-finding) estimate of a target x value (e.g., a percentile)

oldPAVA

Returns standard isotonic-regression estimate, with flexible dose-response input

plot.DRtrace

PLotting Methods for DRtrace, doseResponse Objects

quickInverse

Point and Interval Inverse Estimation ("Dose-Finding"), using CIR and IR

wilsonCI

Standard unordered-Binomial confidence interval utilitlies.

slope

Piecewise-linear local slopes given a (non-strictly) monotone x-y sequence

quickIsotone

One-Stop-shop Forward point and interval estimation via CIR or IR