solveEmax

solveDose

Solve the Emax function for dose or Emax to yield a specified response.

nonlinear

emaxsolve

Bayesian and ML Emax model fitting, graphics and simulation for clinical dose
response. The summary data from the dose response meta-analyses in
Thomas, Sweeney, and Somayaji (2014) <doi:10.1080/19466315.2014.924876> and
Thomas and Roy (2016) <doi:10.1080/19466315.2016.1256229>
Wu, Banerjee, Jin, Menon, Martin, and Heatherington(2017) <doi:10.1177/0962280216684528>
are included
in the package. The prior distributions for the Bayesian analyses default to
the posterior predictive distributions derived from these references.

Neal Thomas

clinDR

Simulation and Analysis Tools for Clinical Dose Response
Modeling

Jing Wu

Mike K. Smith

emaxsolve function

<dl>	<dt>target</dt>
<dd>The targetted response. If the Emax model is specified
 on the logit scale for binary data, <code>target</code> and 
 <code>e0</code> must be logit transformed also.</dd>	<dt>dose</dt>
<dd>The dose yielding target. It is specifed for <code>solveEmax</code>, and 
			returned for <code>solveDose</code></dd>	<dt>led50, lambda, e0</dt>
<dd>Emax model parameters (ed50 log transformed)</dd>	<dt>emax</dt>
<dd>The Emax model parameter for solveDose. The value returned
			for <code>solveEmax</code></dd>	<dt>pboadj</dt>
<dd>When <code>TRUE</code>, target is placebo-adjusted.</dd></dl>

Arguments

Author

Solve Emax function for target value — emaxsolve

<dl>

	<dt>target</dt>
<dd>The targetted response. If the Emax model is specified
 on the logit scale for binary data, <code>target</code> and 
 <code>e0</code> must be logit transformed also.</dd>

	<dt>dose</dt>
<dd>The dose yielding target. It is specifed for <code>solveEmax</code>, and 
			returned for <code>solveDose</code></dd>

	<dt>led50, lambda, e0</dt>
<dd>Emax model parameters (ed50 log transformed)</dd>

	<dt>emax</dt>
<dd>The Emax model parameter for solveDose. The value returned
			for <code>solveEmax</code></dd>

	<dt>pboadj</dt>
<dd>When <code>TRUE</code>, target is placebo-adjusted.</dd>

</dl>

emaxsolve: Solve Emax function for target value

Description

Usage

Arguments

Author

See Also

Examples