calc_kel_double_tdm

Calculate elimination rate when given two TDM samples

Provides equations commonly used in clinical
pharmacokinetics and clinical pharmacology, such as equations
for dose individualization, compartmental pharmacokinetics,
drug exposure, anthropomorphic calculations, clinical
chemistry, and conversion of common clinical parameters. Where
possible and relevant, it provides multiple published and
peer-reviewed equations within the respective R function.

Ron Keizer

clinPK

Clinical Pharmacokinetics Toolkit

Jasmine Hughes

Dominic Tong

Kara Woo

InsightRX 

calc_kel_double_tdm function

<dl><dt>dose</dt>
<dd>dose amount</dd>
<dt>t</dt>
<dd>time or time after dose, vector of size 2</dd>
<dt>dv</dt>
<dd>observed value, vector of size 2</dd>
<dt>tau</dt>
<dd>dosing interval</dd>
<dt>t_inf</dt>
<dd>infusion time</dd>
<dt>V</dt>
<dd>if specified, use that (empiric) value and don't estimate from data. Default `NULL`.</dd>
<dt>steady_state</dt>
<dd>samples taken at steady state? Only influences AUCtau.</dd>
<dt>return_parameters</dt>
<dd>return all parameters instead of only kel?</dd></dl>

Arguments

Calculate elimination rate when given two TDM samples — calc_kel_double_tdm

<dl>

<dt>dose</dt>
<dd>dose amount</dd>


<dt>t</dt>
<dd>time or time after dose, vector of size 2</dd>


<dt>dv</dt>
<dd>observed value, vector of size 2</dd>


<dt>tau</dt>
<dd>dosing interval</dd>


<dt>t_inf</dt>
<dd>infusion time</dd>


<dt>V</dt>
<dd>if specified, use that (empiric) value and don't estimate from data. Default `NULL`.</dd>


<dt>steady_state</dt>
<dd>samples taken at steady state? Only influences AUCtau.</dd>


<dt>return_parameters</dt>
<dd>return all parameters instead of only kel?</dd>

</dl>

calc_kel_double_tdm: Calculate elimination rate when given two TDM samples

Description

Usage

Arguments

Examples