calc_kel_single_tdm

Using iterative k_el calculation, and based on given Volume

Provides equations commonly used in clinical
pharmacokinetics and clinical pharmacology, such as equations
for dose individualization, compartmental pharmacokinetics,
drug exposure, anthropomorphic calculations, clinical
chemistry, and conversion of common clinical parameters. Where
possible and relevant, it provides multiple published and
peer-reviewed equations within the respective R function.

Ron Keizer

clinPK

Clinical Pharmacokinetics Toolkit

Jasmine Hughes

Dominic Tong

Kara Woo

InsightRX 

calc_kel_single_tdm function

<dl><dt>dose</dt>
<dd>dose amount</dd>
<dt>V</dt>
<dd>volume of distribution</dd>
<dt>t</dt>
<dd>time or time after dose</dd>
<dt>dv</dt>
<dd>observed value</dd>
<dt>tau</dt>
<dd>dosing interval</dd>
<dt>t_inf</dt>
<dd>infusion time</dd>
<dt>kel_init</dt>
<dd>estimate of elimination rate</dd>
<dt>n_iter</dt>
<dd>number of iterations to improve estimate of elimination rate</dd>
<dt>learn_rate</dt>
<dd>default is 0.2</dd></dl>

Arguments

Calculate elimination rate when given a single TDM sample — calc_kel_single_tdm

<dl>

<dt>dose</dt>
<dd>dose amount</dd>


<dt>V</dt>
<dd>volume of distribution</dd>


<dt>t</dt>
<dd>time or time after dose</dd>


<dt>dv</dt>
<dd>observed value</dd>


<dt>tau</dt>
<dd>dosing interval</dd>


<dt>t_inf</dt>
<dd>infusion time</dd>


<dt>kel_init</dt>
<dd>estimate of elimination rate</dd>


<dt>n_iter</dt>
<dd>number of iterations to improve estimate of elimination rate</dd>


<dt>learn_rate</dt>
<dd>default is 0.2</dd>

</dl>

calc_kel_single_tdm: Calculate elimination rate when given a single TDM sample

Description

Usage

Arguments

Examples