pk_1cmt_bolus_cmin_ss

Takes single values for dose or model parameters, or vector of either dose or parameters (but not both).

Provides equations commonly used in clinical
pharmacokinetics and clinical pharmacology, such as equations
for dose individualization, compartmental pharmacokinetics,
drug exposure, anthropomorphic calculations, clinical
chemistry, and conversion of common clinical parameters. Where
possible and relevant, it provides multiple published and
peer-reviewed equations within the respective R function.

Ron Keizer

clinPK

Clinical Pharmacokinetics Toolkit

Jasmine Hughes

Dominic Tong

Kara Woo

InsightRX 

pk_1cmt_bolus_cmin_ss function

<dl><dt>dose</dt>
<dd>dose</dd>
<dt>tau</dt>
<dd>dosing interval</dd>
<dt>CL</dt>
<dd>clearance</dd>
<dt>V</dt>
<dd>volume of distrubition</dd>
<dt>ruv</dt>
<dd>residual variability, specified as list with optional arguments for proportional, additive, or exponential components, e.g. `list(prop=0.1, add=1, exp=0)`</dd></dl>

Arguments

Cmin (trough) for linear 1-compartment PK model at steady state, bolus dosing — pk_1cmt_bolus_cmin_ss

<dl>

<dt>dose</dt>
<dd>dose</dd>


<dt>tau</dt>
<dd>dosing interval</dd>


<dt>CL</dt>
<dd>clearance</dd>


<dt>V</dt>
<dd>volume of distrubition</dd>


<dt>ruv</dt>
<dd>residual variability, specified as list with optional arguments for proportional, additive, or exponential components, e.g. `list(prop=0.1, add=1, exp=0)`</dd>

</dl>

pk_1cmt_bolus_cmin_ss: Cmin (trough) for linear 1-compartment PK model at steady state, bolus dosing

Description

Usage

Arguments

Examples