pk_1cmt_inf_dose_for_range

Calculate dose based on a given AUC24, Cmax, and Cmin, assuming 1-compartment model

Provides equations commonly used in clinical
pharmacokinetics and clinical pharmacology, such as equations
for dose individualization, compartmental pharmacokinetics,
drug exposure, anthropomorphic calculations, clinical
chemistry, and conversion of common clinical parameters. Where
possible and relevant, it provides multiple published and
peer-reviewed equations within the respective R function.

Ron Keizer

clinPK

Clinical Pharmacokinetics Toolkit

Jasmine Hughes

Dominic Tong

Kara Woo

InsightRX 

pk_1cmt_inf_dose_for_range function

<dl><dt>target</dt>
<dd>numeric value of target</dd>
<dt>type</dt>
<dd>target type, one of `auc`, `auc24`, `ctrough`, `cmin`</dd>
<dt>conc_range</dt>
<dd>concentration range to stay within, vector of length 2</dd>
<dt>parameters</dt>
<dd>list of `CL` and `V`, or `KEL` and `CL`</dd>
<dt>interval</dt>
<dd>dosing interval</dd>
<dt>t_inf</dt>
<dd>infusion time</dd>
<dt>optimize_interval</dt>
<dd>find optimal interval (to stay within `conc_range`?</dd>
<dt>round_interval</dt>
<dd>round interval to nearest nominal interval?</dd></dl>

Arguments

Calculate dose based on a given AUC24, Cmax, and Cmin, assuming 1-compartment model — pk_1cmt_inf_dose_for_range

<dl>

<dt>target</dt>
<dd>numeric value of target</dd>


<dt>type</dt>
<dd>target type, one of `auc`, `auc24`, `ctrough`, `cmin`</dd>


<dt>conc_range</dt>
<dd>concentration range to stay within, vector of length 2</dd>


<dt>parameters</dt>
<dd>list of `CL` and `V`, or `KEL` and `CL`</dd>


<dt>interval</dt>
<dd>dosing interval</dd>


<dt>t_inf</dt>
<dd>infusion time</dd>


<dt>optimize_interval</dt>
<dd>find optimal interval (to stay within `conc_range`?</dd>


<dt>round_interval</dt>
<dd>round interval to nearest nominal interval?</dd>

</dl>

pk_1cmt_inf_dose_for_range: Calculate dose based on a given AUC24, Cmax, and Cmin, assuming 1-compartment model

Description

Usage

Arguments