clinPK (version 0.13.0)

pk_1cmt_oral: Concentration predictions for 1-compartmental oral PK model after single or multiple bolus doses

Description

Concentration predictions for 1-compartmental oral PK model after single or multiple bolus doses

Usage

pk_1cmt_oral(
  t = c(0:24),
  dose = 100,
  tau = 12,
  KA = 1,
  CL = 3,
  V = 30,
  F = 1,
  ruv = NULL
)

Arguments

t

vector of time

dose

dose

tau

dosing interval

KA

absorption rate

CL

clearance

V

volume of distribution

F

bioavailability, commonly between 0 an 1.

ruv

residual error (list)

References

Garrett ER. The Bateman function revisited: a critical reevaluation of the quantitative expressions to characterize concentrations in the one compartment body model as a function of time with first-order invasion and first-order elimination. J Pharmacokinet Biopharm (1994) 22(2):103-128.

Bialer M. A simple method for determining whether absorption and elimination rate constants are equal in the one-compartment open model with first-order processes. J Pharmacokinet Biopharm (1980) 8(1):111-113

Nielsen JC, Hutmacher MM et al. J Pharmacokinet Pharmacodyn. 2012 Dec;39(6):619-34. doi: 10.1007/s10928-012-9274-0. Epub 2012 Sep 23.

https://static-content.springer.com/esm/art

Examples

pk_1cmt_oral(dose = 500, tau = 12, CL = 5, V = 50, KA = 1)