clinPK (version 0.13.0)

pk_2cmt_inf_ss: Concentration predictions for 2-compartmental PK model with infusion dosing at steady state

Description

Concentration predictions for 2-compartmental PK model with infusion dosing at steady state

Usage

pk_2cmt_inf_ss(
  t = c(0:24),
  dose = 100,
  t_inf = 1,
  tau = 12,
  CL = 3,
  V = 30,
  Q = 2,
  V2 = 20,
  ruv = NULL
)

Arguments

t

vector of time

dose

dose

t_inf

infusion time

tau

dosing interval

CL

clearance

V

volume of distribution

Q

inter-compartimental clearance

V2

volume of peripheral compartment

ruv

residual variability, specified as list with optional arguments for proportional, additive, or exponential components, e.g. `list(prop=0.1, add=1, exp=0)`

Examples

pk_2cmt_inf_ss(
  dose = 1000, tau = 12, t_inf = 2,
  CL = 5, V = 50, Q = 20, V2 = 200)