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clinfun (version 1.0.15)

Clinical Trial Design and Data Analysis Functions

Description

Utilities to make your clinical collaborations easier if not fun. It contains functions for designing studies such as Simon 2-stage and group sequential designs and for data analysis such as Jonckheere-Terpstra test and estimating survival quantiles.

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Version

Install

install.packages('clinfun')

Monthly Downloads

2,030

Version

1.0.15

License

GPL (>= 2)

Maintainer

Venkatraman E Seshan

Last Published

April 13th, 2018

Functions in clinfun (1.0.15)

ktau

Kendall's tau-b estimate
roc.perm.test

Permutation test to compare ROC curve
toxbdry

Stopping rule for toxicity monitoring
twostage.inference

Inference following a two-stage design for binary response
ROCanalysis

Functions to plot and compare ROC curves.
coxphERR

Heller Explained Relative Risk
clinfun-internal

Internal clinfun functions
gsdesign

Group Sequential Designs
coxphCPE

Gonen \& Heller Concordance Probability Estimate
calogrank

Survival curves analysis of covariance
roc.curve

Empirical ROC curve
aucVardiTest

Two-Sample Tests for Growth Curves under Dependent Right Censoring
fedesign

Trial Designs Based On Fisher's Exact Test
coxphQuantile

Survival time quantile as a function of covariate
jonckheere.test

Exact/permutation version of Jonckheere-Terpstra test
power.ladesign

Power of k-sample rank test under Lehmann alternative
pselect

Probability of selection under pick the winner rule
ph2single

Exact single stage Phase II design
deltaAUC

Comparing the AUC from ROC curves from nested binary regression
roc.area.test

Nonparametric area under the ROC curve
permlogrank

Permutation version of survdiff
oc.twostage.bdry

Two-stage boundary operating characteristics
ph2simon

Simon's 2-stage Phase II design