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clinfun (version 1.1.6)

Clinical Trial Design and Data Analysis Functions

Description

Utilities to make your clinical collaborations easier if not fun. It contains functions for designing studies such as Simon 2-stage and group sequential designs and for data analysis such as Jonckheere-Terpstra test and estimating survival quantiles.

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Version

Install

install.packages('clinfun')

Monthly Downloads

2,210

Version

1.1.6

License

GPL (>= 2)

Maintainer

Venkatraman E Seshan

Last Published

August 29th, 2026

Functions in clinfun (1.1.6)

twostage.admissible

Admissible design options between Minimax and Optimal

Probability of selection under pick the winner rule

twostage.inference

Inference following a two-stage design for binary response

Permutation test to compare ROC curve

Stopping rule for toxicity/futility monitoring

Functions to plot and compare ROC curves.

Two-Sample Tests for Growth Curves under Dependent Right Censoring

Empirical ROC curve

Power of k-sample rank test under Lehmann alternative

Heller Explained Relative Risk

clinfun-internal

Internal clinfun functions

jonckheere.test

Exact/permutation version of Jonckheere-Terpstra test

Nonparametric area under the ROC curve

Group Sequential Designs

Kendall's tau-b estimate

Survival time quantile as a function of covariate

Comparing the AUC from ROC curves from nested binary regression

oc.twostage.bdry

Two-stage boundary operating characteristics

Concordance Probability Estimate for Cox model

Permutation version of survdiff

Exact single stage Phase II design

Trial Designs Based On Fisher's Exact Test

Survival curves analysis of covariance

Simon's 2-stage Phase II design