Using alanine aminotransferase and alkaline phosphatase calculate an index that can distinguish between hepatocellulal, cholestatic, or a combination of both in patients presenting with acute liver injury. Recommended for use in risk stratification and diagnosis by the American College of Gastroenterology.
Usage
rfactor(alt, alp)
Value
A numeric value/vector with predicted cause of liver injury.
Arguments
alt
Numeric value of alanine aminotransferase (U/L).
alp
Numeric value of alkaline phosphatase (U/L).
References
Bénichou C. Criteria of drug-induced liver disorders. Report of an international consensus meeting. J Hepatol. 1990;11(2):272-6.
Chalasani NP, Hayashi PH, Bonkovsky HL, et al. ACG Clinical Guideline: the diagnosis and management of idiosyncratic drug-induced liver injury. Am J Gastroenterol. 2014;109(7):950-66.