cliot (version 1.0.0)

acetaminophen_nomogram: Acetaminophen Overdose NAC Dosing (Rumack-Matthew Nomogram)

Description

Determines the need for N-acetylcysteine (NAC) treatment following a single acute acetaminophen ingestion. The function utilizes the Rumack-Matthew Nomogram logic, specifically the "Treatment Line" (starting at 150 mcg/mL at 4 hours), to interpret serum acetaminophen levels obtained between 4 and 24 hours post-ingestion.

Usage

acetaminophen_nomogram(time_ingestion_hrs, acetaminophen_level, units = "mcg/mL")

Value

A list containing:

Standardized_Level_mcg_mL

The input level converted to mcg/mL.

Treatment_Threshold_mcg_mL

The nomogram threshold value for the specific time provided.

Recommendation

Clinical guidance based on whether the level falls above or below the treatment line.

Arguments

time_ingestion_hrs

Numeric. Time passed since the ingestion in hours. The nomogram is valid only for single acute ingestions between 4 and 24 hours.

acetaminophen_level

Numeric. The measured serum acetaminophen concentration.

units

String. Units of the concentration measurement. Options: "mcg/mL" (default) "mg/L" "mg/dL" "micromol/L"

References

Rumack BH, Matthew H. Acetaminophen poisoning and toxicity. Pediatrics. 1975;55(6):871-876.

Examples

# Example 1: Treatment Needed
# 8 hours post-ingestion, Level 100 mcg/mL
# Threshold at 8 hours is 75 mcg/mL -> Above line
acetaminophen_nomogram(8, 100, "mcg/mL")

# Example 2: No Treatment
# 5 hours post-ingestion, Level 100 mcg/mL
# Threshold at 5 hours is ~126 mcg/mL -> Below line
acetaminophen_nomogram(5, 100, "mcg/mL")

# Example 3: Different Units
# 4 hours post, Level 20 mg/dL -> Converts to 200 mcg/mL (Above 150 threshold)
acetaminophen_nomogram(4, 20, "mg/dL")