cliot (version 1.0.0)

age_adjusted_esr_crp: Age-Adjusted ESR and CRP

Description

Calculates the upper limit of normal for Erythrocyte Sedimentation Rate (ESR) and C-Reactive Protein (CRP) based on patient age and sex. Standard reference ranges often misclassify elderly patients as having elevated inflammatory markers due to the natural physiological rise of these markers with age. These formulas provide a more accurate cutoff for inflammation.

Usage

age_adjusted_esr_crp(age, sex, esr = NULL, crp = NULL)

Value

A list containing:

Calculated_ESR_Upper_Limit

The age-adjusted upper limit for ESR (Formula: Male=Age/2; Female=(Age+10)/2).

Calculated_CRP_Upper_Limit

The age-adjusted upper limit for CRP (Formula: Male=Age/50; Female=Age/50 + 0.6).

Patient_Values

The input values provided.

Interpretation

Status ("Normal" or "Elevated") for the provided values against the calculated limits.

Arguments

age

Numeric. Patient age in years.

sex

String. Patient sex ("Male" or "Female").

esr

Numeric (Optional). Patient's measured ESR (mm/hr). If provided, the function determines if it is elevated.

crp

Numeric (Optional). Patient's measured CRP (mg/dL). If provided, the function determines if it is elevated.

References

Miller A, Green M, Robinson D. Simple rule for calculating normal erythrocyte sedimentation rate. Br Med J (Clin Res Ed). 1983;286(6361):266.

Wener MH, Daum PR, McQuillan GM. The influence of age, sex, and race on the upper reference limit of serum C-reactive protein concentration. J Rheumatol. 2000;27(10):2351-2359.

Examples

# Example 1: 70-year-old Female
# ESR Limit = (70 + 10) / 2 = 40
# CRP Limit = (70 / 50) + 0.6 = 1.4 + 0.6 = 2.0
age_adjusted_esr_crp(70, "female")

# Example 2: Evaluation of specific labs
# 60-year-old Male with ESR 25 and CRP 1.5
# ESR Limit = 30 (Normal); CRP Limit = 1.2 (Elevated)
age_adjusted_esr_crp(60, "male", esr = 25, crp = 1.5)