cliot (version 1.0.0)

ascod_stroke_phenotype: ASCOD Phenotyping for Ischemic Stroke

Description

Generates the ASCOD phenotype string for ischemic stroke characterization. The ASCOD classification system characterizes stroke based on the presence and likelihood of five underlying pathologies: Atherosclerosis (A), Small vessel disease (S), Cardiac pathology (C), Other causes (O), and Dissection (D). Each category is graded based on the strength of the causal link.

Usage

ascod_stroke_phenotype(a_grade, s_grade, c_grade, o_grade, d_grade)

Value

A list containing:

ASCOD_Phenotype

The formatted phenotype string (e.g., "A1-S3-C0-O9-D0").

Interpretation

A breakdown of the clinical significance for each category.

Arguments

a_grade

Numeric (0, 1, 2, 3, or 9). Grade for Atherosclerosis.

s_grade

Numeric (0, 1, 2, 3, or 9). Grade for Small Vessel Disease.

c_grade

Numeric (0, 1, 2, 3, or 9). Grade for Cardiac Pathology.

o_grade

Numeric (0, 1, 2, 3, or 9). Grade for Other Causes.

d_grade

Numeric (0, 1, 2, 3, or 9). Grade for Dissection.

Details

Grading Key: 1: Potential Cause (Disease present and potentially causal). 2: Uncertain Cause (Disease present but causal link uncertain). 3: Unlikely Cause (Disease present but unlikely to be the cause). 0: Absent (No disease found). 9: Insufficient Workup (Grading not possible).

References

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Hennerici MG. The ASCOD phenotyping of ischemic stroke (Updated ASCOD I). Cerebrovasc Dis. 2013;36(1):1-5. doi:10.1159/000352050

Examples

# Example 1: Cardioembolic Stroke
# Atherosclerosis absent (0), Small vessel unlikely (3),
# Cardiac potential (1), Other insuff (9), Dissection absent (0)
ascod_stroke_phenotype(0, 3, 1, 9, 0)

# Example 2: Mixed Etiology
# Atherosclerosis potential (1), Small vessel potential (1), others absent
ascod_stroke_phenotype(1, 1, 0, 0, 0)