cliot (version 1.0.0)

ball_score_cll: BALL Score for Relapsed/Refractory CLL

Description

Calculates the BALL (Beta-2 microglobulin, Anemia, LDH, Last therapy) score to prognosticate Overall Survival in patients with relapsed or refractory Chronic Lymphocytic Leukemia (CLL). This score uses four readily available clinical variables to stratify patients into Low, Intermediate, or High risk categories.

Usage

ball_score_cll(beta2_microglobulin_mg_l, hemoglobin_g_dl, sex, ldh_elevated,
               last_therapy_pfs_lt_24mo)

Value

A list containing:

BALL_Score

The calculated score (Range 0-4).

Risk_Group

Classification (Low 0-1, Intermediate 2-3, High 4).

Est_2Yr_Overall_Survival

Estimated 2-year Overall Survival percentage based on the validation cohort.

Arguments

beta2_microglobulin_mg_l

Numeric. Serum Beta-2 microglobulin level in mg/L. (> 3.5 mg/L adds +1 point).

hemoglobin_g_dl

Numeric. Hemoglobin level in g/dL. Anemia (Male < 12 g/dL; Female < 11 g/dL) adds +1 point.

sex

String. Patient sex ("Male" or "Female"). Used to determine the anemia threshold.

ldh_elevated

Numeric (0 or 1). Is Lactate Dehydrogenase (LDH) greater than the Upper Limit of Normal? (1 = Yes, +1 point).

last_therapy_pfs_lt_24mo

Numeric (0 or 1). Was the duration of response (progression-free survival) to the last prior therapy < 24 months? (1 = Yes, +1 point).

References

Grosicki S, et al. The BALL score: a new prognostic model for relapsed/refractory chronic lymphocytic leukemia patients. Leuk Lymphoma. 2020.

Examples

# Example 1: High Risk
# B2M 5.0 (+1), Hb 10 (Male, +1), High LDH (+1), Short prior remission (+1)
# Score = 4
ball_score_cll(5.0, 10.0, "male", 1, 1)

# Example 2: Low Risk
# B2M 2.0 (0), Hb 13 (Female, 0), Normal LDH (0), Long prior remission (0)
# Score = 0
ball_score_cll(2.0, 13.0, "female", 0, 0)