cliot (version 1.0.0)

binet_staging_cll: Binet Staging System for Chronic Lymphocytic Leukemia (CLL)

Description

Classifies Chronic Lymphocytic Leukemia (CLL) into three prognostic stages (A, B, or C) based on the number of involved lymphoid areas and the presence of anemia or thrombocytopenia.

Usage

binet_staging_cll(hemoglobin_g_dl, platelets_per_ul, cervical_nodes,
                  axillary_nodes, inguinal_nodes, liver_spleen_palpable)

Value

A list containing:

Binet_Stage

The calculated stage (A, B, or C).

Criteria_Description

Description of the specific criteria met.

Median_Survival

Estimated median survival based on historical data.

Arguments

hemoglobin_g_dl

Numeric. Hemoglobin level in g/dL. (Threshold < 10 g/dL).

platelets_per_ul

Numeric. Platelet count. (Threshold < 100,000/uL).

cervical_nodes

Numeric (0 or 1). Enlargement of cervical lymph nodes. (1 = Yes).

axillary_nodes

Numeric (0 or 1). Enlargement of axillary lymph nodes. (1 = Yes).

inguinal_nodes

Numeric (0 or 1). Enlargement of inguinal lymph nodes. (1 = Yes).

liver_spleen_palpable

Numeric (0 or 1). Palpable hepatomegaly or splenomegaly. (1 = Yes).

References

Binet JL, Auquier A, Dighiero G, et al. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer. 1981;48(1):198-206. doi:10.1002/1097-0142(19810701)48:1<198::aid-cncr2820480131>3.0.co;2-v

Examples

# Example 1: Stage C
# Hb 9.0 (Anemia), Plt 150k, 1 area involved
binet_staging_cll(9.0, 150000, 1, 0, 0, 0)

# Example 2: Stage A
# Hb 14, Plt 200k, 1 area involved (Cervical)
binet_staging_cll(14, 200000, 1, 0, 0, 0)

# Example 3: Stage B
# Hb 13, Plt 180k, 3 areas involved (Cervical, Axillary, Spleen)
binet_staging_cll(13, 180000, 1, 1, 0, 1)