cliot (version 1.0.0)

calculate_tpa_stroke_dosing: tPA (Tissue Plasminogen Activator) Dosing Calculator for Stroke

Description

Calculates the recommended dosing of Alteplase (tPA) for the treatment of acute ischemic stroke. The standard dose is 0.9 mg/kg, with a maximum total dose of 90 mg. 10% of the total dose is administered as an initial bolus over 1 minute, and the remaining 90% is infused over 60 minutes.

Usage

calculate_tpa_stroke_dosing(weight_kg)

Value

A list containing:

Total_Dose_mg

The total calculated dose (Max 90 mg).

Bolus_Dose_mg

The 10% bolus dose to be given over 1 minute.

Infusion_Dose_mg

The 90% remaining dose to be infused over 60 minutes.

Discard_Amount_from_100mg_Vial

The amount of medication to discard from a standard 100 mg vial to prevent overdose.

Arguments

weight_kg

Numeric. The patient's weight in kilograms.

References

The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995;333(24):1581-1587. doi:10.1056/NEJM199512143332401

Examples

# Example 1: 70 kg patient
# Total = 0.9 * 70 = 63 mg
# Bolus = 6.3 mg, Infusion = 56.7 mg
calculate_tpa_stroke_dosing(70)

# Example 2: 110 kg patient (Max dose applies)
# Total = 0.9 * 110 = 99 -> Capped at 90 mg
# Bolus = 9 mg, Infusion = 81 mg
calculate_tpa_stroke_dosing(110)