cliot (version 1.0.0)

cci_platelet_transfusion: Corrected Count Increment (CCI) for Platelet Transfusion

Description

Calculates the Corrected Count Increment (CCI) to evaluate the efficacy of platelet transfusions. This metric adjusts the observed rise in platelet count for the patient's body surface area and the dose of platelets administered. It is the standard method for diagnosing platelet refractoriness.

Usage

cci_platelet_transfusion(post_platelet_count, pre_platelet_count, bsa,
                         platelets_transfused_10_11)

Value

A list containing:

CCI_Value

The calculated Corrected Count Increment.

Interpretation

Clinical interpretation regarding refractoriness (typically defined as CCI < 7500 at 1 hour).

Arguments

post_platelet_count

Numeric. Platelet count measured 10-60 minutes after transfusion (cells/uL or /mm3).

pre_platelet_count

Numeric. Platelet count measured prior to transfusion (cells/uL or /mm3).

bsa

Numeric. Patient's Body Surface Area in m^2.

platelets_transfused_10_11

Numeric. The number of platelets transfused in units of 10^11. (e.g., for 3.0 x 10^11 platelets, enter 3.0). A typical apheresis unit contains ~3.0-4.0 x 10^11 platelets. A pooled random donor unit contains ~0.5-0.8 x 10^11 per unit.

References

Hod E, Schwartz J. Platelet transfusion refractoriness. Br J Haematol. 2008;142(3):348-360. doi:10.1111/j.1365-2141.2008.07189.x

Examples

# Example 1: Successful Transfusion
# Post 40k, Pre 10k, BSA 1.8, Transfused 3.0 x 10^11
# CCI = ((40000 - 10000) * 1.8) / 3.0 = 18000
cci_platelet_transfusion(40000, 10000, 1.8, 3.0)

# Example 2: Refractory
# Post 12k, Pre 10k, BSA 2.0, Transfused 3.0 x 10^11
# CCI = ((12000 - 10000) * 2.0) / 3.0 = 1333
cci_platelet_transfusion(12000, 10000, 2.0, 3.0)