cliot (version 1.0.0)

cll_ipi_score: International Prognostic Index for Chronic Lymphocytic Leukemia (CLL-IPI)

Description

Calculates the CLL-IPI score to predict 5-year overall survival and stratify risk in patients with Chronic Lymphocytic Leukemia. The index integrates genetic, biochemical, and clinical variables.

Usage

cll_ipi_score(tp53_deleted_or_mutated, ighv_unmutated,
              beta2_microglobulin_gt_3_5, clinical_stage_advanced, age_gt_65)

Value

A list containing:

CLL_IPI_Score

The calculated risk score (Range 0-10).

Risk_Group

Classification (Low 0-1, Intermediate 2-3, High 4-6, Very High 7-10).

Est_5_Year_Overall_Survival

Estimated 5-year survival probability.

Recommendation

General treatment guidance based on risk group.

Arguments

tp53_deleted_or_mutated

Numeric (0 or 1). Presence of del(17p) and/or TP53 mutation. (1 = Yes, +4 points).

ighv_unmutated

Numeric (0 or 1). IGHV mutational status is unmutated. (1 = Yes, +2 points).

beta2_microglobulin_gt_3_5

Numeric (0 or 1). Serum Beta-2 Microglobulin > 3.5 mg/L. (1 = Yes, +2 points).

clinical_stage_advanced

Numeric (0 or 1). Rai Stage I-IV or Binet Stage B-C. (1 = Yes, +1 point).

age_gt_65

Numeric (0 or 1). Patient age > 65 years. (1 = Yes, +1 point).

References

Kutsch N, Bahlo J, Robrecht S, et al. International Prognostic Index for Chronic Lymphocytic Leukemia (CLL-IPI): an international meta-analysis. Lancet Oncol. 2016;17(6):779-790. doi:10.1016/S1470-2045(16)30029-8

Examples

# Example 1: Very High Risk
# TP53 deleted (+4), IGHV unmutated (+2), B2M > 3.5 (+2), Stage I (+1), Age 70 (+1)
# Score = 10
cll_ipi_score(1, 1, 1, 1, 1)

# Example 2: Low Risk
# No mutations, Normal B2M, Stage 0, Age 60
# Score = 0
cll_ipi_score(0, 0, 0, 0, 0)