cliot (version 1.0.0)

cp_aki_risk_score: CP-AKI Risk Calculator

Description

Calculates the Cisplatin-Associated Acute Kidney Injury (CP-AKI) Risk Score. This tool estimates the probability of developing acute kidney injury in patients undergoing treatment with intravenous cisplatin. The score incorporates patient demographics, vital signs, and laboratory values to stratify risk.

Usage

cp_aki_risk_score(age_ge_61, systolic_bp_gt_140, low_hemoglobin, low_albumin,
                  low_potassium, low_calcium, low_magnesium, high_creatinine_dose,
                  high_cisplatin_dose)

Value

A list containing:

CP_AKI_Score

The calculated risk score (Range 0-15.5).

Risk_Group

Risk classification (Low, Moderate, High).

Est_Risk_AKI

Estimated probability of developing AKI.

Arguments

age_ge_61

Numeric (0 or 1). Age >= 61 years. (1 = Yes, +1.5 points).

systolic_bp_gt_140

Numeric (0 or 1). Systolic Blood Pressure > 140 mmHg. (1 = Yes, +1.5 points).

low_hemoglobin

Numeric (0 or 1). Hemoglobin (Male <= 13.4 g/dL; Female <= 12.4 g/dL). (1 = Yes, +1.0 point).

low_albumin

Numeric (0 or 1). Serum Albumin <= 3.9 g/dL. (1 = Yes, +2.5 points).

low_potassium

Numeric (0 or 1). Serum Potassium <= 4.0 mmol/L. (1 = Yes, +2.0 points).

low_calcium

Numeric (0 or 1). Serum Calcium <= 9.3 mg/dL. (1 = Yes, +1.5 points).

low_magnesium

Numeric (0 or 1). Serum Magnesium <= 1.8 mg/dL. (1 = Yes, +1.5 points).

high_creatinine_dose

Numeric (0 or 1). Dose of Cisplatin per Serum Creatinine level >= 60 mg/mg. (1 = Yes, +1.5 points).

high_cisplatin_dose

Numeric (0 or 1). Dose of Cisplatin >= 50 mg. (1 = Yes, +2.5 points).

References

Motwani SS, et al. Development and Validation of a Risk Prediction Model for Acute Kidney Injury After the First Course of Cisplatin. J Clin Oncol. 2018.

Examples

# Example 1: High Risk
# Age 65 (+1.5), SBP 150 (+1.5), Low Alb (+2.5), High Cisplatin (+2.5)
# Score = 8.0
cp_aki_risk_score(1, 1, 0, 1, 0, 0, 0, 0, 1)

# Example 2: Low Risk
# Age 40 (0), Normal labs, Low Cisplatin Dose
# Score = 0
cp_aki_risk_score(0, 0, 0, 0, 0, 0, 0, 0, 0)