cliot (version 1.0.0)

delta_p_lems_score: Dutch-English LEMS Tumor Association Prediction (DELTA-P) Score

Description

Calculates the DELTA-P score to predict the likelihood of Small Cell Lung Cancer (SCLC) in patients with Lambert-Eaton Myasthenic Syndrome (LEMS). The score assigns 1 point for each of six risk factors present at diagnosis: Bulbar weakness, Erectile dysfunction (in males), Weight loss >= 5%, Tobacco use at onset, Age at onset >= 50 years, and Karnofsky Performance Status < 70.

Usage

delta_p_lems_score(bulbar_weakness, erectile_dysfunction_male,
                   weight_loss_ge_5pct, tobacco_at_onset, age_onset_ge_50,
                   kps_lt_70)

Value

A list containing:

DELTA_P_Score

The calculated score (Range 0-6).

SCLC_Probability

Estimated percentage probability of having SCLC.

Arguments

bulbar_weakness

Numeric (0 or 1). Presence of dysarthria, dysphagia, chewing weakness, or neck weakness. (1 = Yes).

erectile_dysfunction_male

Numeric (0 or 1). Presence of erectile dysfunction in a male patient. (1 = Yes, 0 = No/Female).

weight_loss_ge_5pct

Numeric (0 or 1). Weight loss of 5% or more. (1 = Yes).

tobacco_at_onset

Numeric (0 or 1). Smoking at the time of LEMS onset. (1 = Yes).

age_onset_ge_50

Numeric (0 or 1). Age at onset of symptoms >= 50 years. (1 = Yes).

kps_lt_70

Numeric (0 or 1). Karnofsky Performance Status < 70 (0-60). (1 = Yes).

References

Titulaer MJ, Maddison P, Sont JK, et al. Clinical Dutch-English Lambert-Eaton myasthenic syndrome (LEMS) tumor association prediction score accurately predicts small-cell lung cancer in the LEMS. J Clin Oncol. 2011;29(7):902-908. doi:10.1200/JCO.2010.32.0440

Examples

# Example 1: Low Risk
# Young female, non-smoker, no weight loss
# Score = 0
delta_p_lems_score(0, 0, 0, 0, 0, 0)

# Example 2: High Risk
# 60yo Male, Smoker, Erectile Dysfunction, Wt Loss
# Score = 1 (Age) + 1 (Sex/ED) + 1 (Wt) + 1 (Smoke) = 4
delta_p_lems_score(0, 1, 1, 1, 1, 0)