cliot (version 1.0.0)

dipss_myelofibrosis: Dynamic International Prognostic Scoring System (DIPSS) for Myelofibrosis

Description

Calculates the DIPSS score to estimate overall survival in patients with primary myelofibrosis. This dynamic scoring system can be used at any point during the disease course, unlike the IPSS which is valid only at diagnosis. The score is based on age, white blood cell count, hemoglobin, peripheral blood blasts, and constitutional symptoms.

Usage

dipss_myelofibrosis(age, hemoglobin_g_dl, wbc_count_10_9_l,
                    circulating_blasts_percent, constitutional_symptoms)

Value

A list containing:

DIPSS_Score

The calculated total score (Range 0-6).

Risk_Category

Risk classification (Low, Int-1, Int-2, High).

Median_Overall_Survival

Estimated median survival time.

Arguments

age

Numeric. Patient age in years. (> 65 years adds +1 point).

hemoglobin_g_dl

Numeric. Hemoglobin level in g/dL. (< 10 g/dL adds +2 points).

wbc_count_10_9_l

Numeric. White Blood Cell count in 10^9/L. (> 25 x 10^9/L adds +1 point).

circulating_blasts_percent

Numeric. Percentage of circulating blasts in peripheral blood. (>= 1% adds +1 point).

constitutional_symptoms

Numeric (0 or 1). Presence of constitutional symptoms (weight loss >10% in 6 months, unexplained fever, or excessive sweating). (1 = Yes, +1 point).

References

Passamonti F, Cervantes F, Vannucchi AM, et al. A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myelofibrosis Research and Treatment). Blood. 2010;115(9):1703-1708. doi:10.1182/blood-2009-09-245837

Examples

# Example 1: High Risk
# Age 70 (+1), Hb 9 (+2), WBC 30 (+1), Blasts 2% (+1), Symptoms Yes (+1)
# Score = 6
dipss_myelofibrosis(70, 9.0, 30, 2, 1)

# Example 2: Intermediate-1
# Age 50 (0), Hb 11 (0), WBC 10 (0), Blasts 0 (0), Symptoms Yes (+1)
# Score = 1
dipss_myelofibrosis(50, 11.0, 10, 0, 1)